公开(公告)号：EP4506020A2

公开(公告)日：2025-02-12

申请号：EP23784017.8

申请日：2023-04-06

Applicant: Tissuelabs Pesquisa E Desenvolvimento Ltda

Inventor： LIGUORI, Gabriel Romero ,  LIGUORI, Tácia Tavares De Aquinas ,  DE SOUZA, Fernanda Carla Bombaldi ,  DE SOUZA, Renata Francielle Bombaldi

IPC: A61L27/14 ,  A61L27/36 ,  A61K35/12 ,  A61K47/06 ,  A61K47/30

Abstract: The present invention is in the field of tissue and organ bioengineering and refers to an enzyme-free process to produce a tissue-specific extracellular matrix solution, based on a decellularized extracellular matrix, comprising: (a) decellularizing a tissue or organ to obtain the isolated extracellular matrix; and (b) hydrolyzing the isolated extracellular matrix in an acidic environment, in the absence of proteolytic enzymes, optionally followed by purification of the solution. Still, the present invention refers to an enzyme-free process to produce a tissue-specific hydrogel. Thus, the present invention also relates to hydrogels produced according to the current processes, and to ancillary inventions, having the tissue-specific extracellular matrix solution, the hydrogel, and/or the products derived from the tissue-specific extracellular matrix solution as the core that connects the inventive aspects disclosed in this document.