-
1.发明公开MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开MICRO或形状3D打印机疫苗制剂PULSATING RELEASE
公开(公告)号：EP3082852A1
公开(公告)日：2016-10-26
申请号：EP14830756.4
申请日：2014-12-16
发明人： JAKLENEC, Ana , GATES, William , ECKHOFF, Philip, A. , NIKOLIC, Boris , WOOD, Lowell, L. , LANGER, Robert, S. , NORMAN, James J , NGUYEN, Thanh Duc , TZENG, Stephany Yi
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/466
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
-
公开(公告)号：EP2979044A1
公开(公告)日：2016-02-03
申请号：EP14775659.7
申请日：2014-03-27
申请人： Tokitae LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.
摘要翻译： 在一些实施例中，基本上热密封的储存容器包括与容器成一体的外部组件和蒸发冷却组件。 在一些实施例中，外部组件包括基本上限定至少一个热控存储区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。 在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸气导管，蒸气导管包括第一端和第二端，第一端连接到蒸发冷却单元，第二端连接到干燥剂单元; 以及附接到蒸汽管道的蒸汽控制单元。
-
公开(公告)号：EP2979044B1
公开(公告)日：2020-10-07
申请号：EP14775659.7
申请日：2014-03-27
申请人： Tokitae LLC
-
-
搜索结果
3 条记录 (耗时 0.008 秒)
