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1.发明公开FERTILITY TEST METHOD, FERTILITY TEST KIT, POLYNUCLEOTIDE, POLYPEPTIDE AND ANTIBODY 有权生育力测试过程中，多核苷酸多肽抗体
公开(公告)号：EP2410050A1
公开(公告)日：2012-01-25
申请号：EP10753285.5
申请日：2010-03-15
CPC分类号： G01N33/689 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2333/99
摘要： An object of the present invention is to provide a test/diagnosis method for fertility which allows the estimation of the possibility of leading to pregnancy based on the ability of sperm to fuse with an egg and the identification of a cause of infertility; and a polynucleotide and a fertility testing kit which are used in the method. The present invention provides a test/diagnosis method for fertility, including a detection step of detecting on a biological sample taken from a human body, the presence or absence of a deletion or mutation in the human PGAM4 gene; a polynucleotide consisting of the base sequence of the human wild-type PGAM4 gene or the base sequence of the translation region of the gene, wherein the polynucleotide consists of a base sequence of 10-100 consecutive bases containing a mutated site of a single base substitution mutation having a high correlation with fertility; and a test kit for fertility comprising a reagent for detecting the presence or absence of a deletion or mutation in the human PGAM4 gene.
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公开(公告)号：EP2410050B1
公开(公告)日：2017-06-21
申请号：EP10753285.5
申请日：2010-03-15
CPC分类号： G01N33/689 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2333/99
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