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公开(公告)号：EP3106128B1
公开(公告)日：2020-12-02
申请号：EP15749638.1
申请日：2015-02-12
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公开(公告)号：EP3603573A1
公开(公告)日：2020-02-05
申请号：EP18775244.9
申请日：2018-03-30
发明人： YAMASHITA, Kyohei , KADOWAKI, Koji , TANAHASHI, Kazuhiro , TANAKA, Nobuaki , YAMADA, Satoshi , TSUCHIKURA, Hiroshi
摘要： An object of the present invention is to provide a tubular structure which has succeeded in achieving excellent puncture resistance as well as maintenance of flexibility in a base by covering the base with a cover having excellent flexibility. The present invention provides a tubular structure including a tubular base and a cover which covers the base, wherein the cover includes a copolymer containing a silicone monomer and a polymerizable monomer having a fluoroalkyl group(s) as monomer units.
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公开(公告)号：EP3085335A1
公开(公告)日：2016-10-26
申请号：EP14871178.1
申请日：2014-12-16
发明人： TSUCHIKURA, Hiroshi , YAMADA, Satoshi , KUWABARA, Atsushi , TOKUDA, Akihiro , TANAHASHI, Kazuhiro , FUJITA, Masaki , KADOWAKI, Koji
CPC分类号： A61F2/0063 , A61F2/06 , A61F2002/0068 , A61L27/18 , A61L27/507 , D03D3/02 , D03D13/008 , D03D15/00 , D10B2509/06 , C08L67/02
摘要： Provided is a textile vascular prosthesis with reduced leakage of blood through the voids between the fibers. In particular, provided is a vascular prosthesis with multi-layer tubular woven structure, the prosthesis comprising two types of yarns, the yarns being a microfiber multifilament yarn with a monofilament fineness of 0.5 dtex or less as a warp yarn for mainly forming an inner layer to be in contact with a blood flow and a multifilament yarn with a monofilament fineness of 1.0 dtex or more as a warp yarn for mainly forming an outer layer, the inner layer having an apparent cover factor of 2000 or more.
摘要翻译： 提供了一种纺织血管假体，其通过纤维之间的空隙减少血液渗漏。 特别地，提供了一种具有多层管状编织结构的血管假体，所述假体包括两种类型的纱线，所述纱线是单丝纤度为0.5dtex以下的超细纤维复丝纱线，作为主要形成内层的经纱 与血流和单丝细度为1.0dtex以上的复丝纱作为主要形成外层的经纱接触，内层的表观覆盖系数为2000以上。
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公开(公告)号：EP3075400A1
公开(公告)日：2016-10-05
申请号：EP14865433.8
申请日：2014-11-27
IPC分类号： A61L33/00
CPC分类号： A61L33/0041 , A61L33/0011 , A61L33/0076 , A61L33/068 , A61L2300/42 , A61L2420/02
摘要： The present invention aims to provide an antithrombogenic material in which an antithrombogenic compound other than heparin or heparin derivatives is immobilized on a base material to prevent elution of the compound having antithrombogenicity from the base material, which antithrombogenic material therefore maintains high antithrombogenicity for a long period. The present invention provides an antithrombogenic material including: a coating material containing a skeletal structure composed of a polymer, a skeletal structure composed of 4-(aminomethyl)benzenecarboxyimidamide or benzene amidine, and a skeletal structure composed of methoxybenzenesulfonic acid amide; and a base material whose surface is coated with the coating material; wherein the coating material is covalently bound to the base material, and the peak abundance ratio of the carbonyl-derived component in the total component of the Cls peak as measured by X-ray photoelectron spectroscopy on the surface is not less than 1.0 atomic percent.
摘要翻译： 本发明的目的在于提供一种抗血栓形成材料，其中除了肝素或肝素衍生物之外的抗血栓形成化合物固定在基材上，以防止具有抗凝血性的化合物从基材中溶出，因此该抗血栓形成材料因此长时间保持高的抗血栓形成性 。 本发明提供一种抗血栓形成材料，包括：包含由聚合物构成的骨架结构的涂层材料，由4-（氨基甲基）苯甲酰亚胺酰胺或苯脒组成的骨架结构，以及由甲氧基苯磺酸酰胺构成的骨架结构; 以及其表面涂覆有所述涂料的基材; 其中涂层材料共价结合到基材上，并且通过表面上的X射线光电子能谱测定的Cls峰的总成分中的羰基衍生成分的峰丰度比不小于1.0原子％。
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公开(公告)号：EP2990010A1
公开(公告)日：2016-03-02
申请号：EP14788777.2
申请日：2014-04-23
发明人： YAMADA, Satoshi , TSUCHIKURA, Hiroshi , TANAKA, Nobuaki , TANAHASHI, Kazuhiro , SAKAGUCHI, Yuka , FUJITA, Masaki , KADOWAKI, Koji
IPC分类号： A61F2/06
CPC分类号： A61F2/89 , A61F2/06 , A61F2210/0076 , A61F2250/0017 , A61F2250/0067 , A61L27/18 , A61L33/068 , D04B21/02 , D10B2509/06 , C08L79/02
摘要： The present invention addresses the problem of providing an artificial blood vessel which is able to retain mechanical properties required for an artificial blood vessel, rarely undergoes the formation of thrombi when grafted into a blood vessel having a small or medium diameter, and has such an excellent cell colonization property that endothelial cells can be colonized rapidly to form an endothelial tissue. Thus, the present invention provides an artificial blood vessel comprising a tubular woven fabric which is composed of at least two types of polyester fibers, i.e., a multifilament yarn A and a multifilament yarn B, and has an inner diameter of 8 mm or less and a layer thickness of 50 µm or more and 250 µm or less, wherein the multifilament yarn A has a single fiber fineness of 1.0 dtex or more and a total fineness of 33 dtex or less, the multifilament yarn B has a single fiber fineness of 0.08 dtex or less and a total fineness of 66 dtex or less, and the multifilament yarn B forms loops on the inner wall surface of the composite tubular woven fabric.
摘要翻译： 本发明解决了提供一种人造血管的问题，该人造血管能够保持人造血管所需的机械性能，当移植到具有小或中等直径的血管中时很少形成血栓，并且具有如此优良的 细胞定殖的性质，即内皮细胞可以迅速定殖以形成内皮组织。 因此，本发明提供了一种人造血管，其包括由至少两种类型的聚酯纤维即复丝纱线A和复丝纱线B组成并且具有8mm或更小的内径的管状织物和 复丝纱线A的单丝纤度为1.0dtex以上且总纤度为33dtex以下的层厚为50μm以上且250μm以下，复丝纱线B的单纤维纤度为0.08 dtex以下，总纤度为66dtex以下，并且复丝纱线B在复合筒状织物的内壁表面上形成环。
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6.发明授权
公开(公告)号：EP2518100B1
公开(公告)日：2015-02-18
申请号：EP10839438.8
申请日：2010-12-22
IPC分类号： C08G81/00 , A61L33/00 , C08F8/34 , C08F16/06 , C08F18/08 , C08F26/10 , C08G77/392 , C08G77/46 , C08G83/00 , C08G85/00
CPC分类号： C08G85/004 , A61L33/0011 , A61L2400/18
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7.发明公开
公开(公告)号：EP2832381A1
公开(公告)日：2015-02-04
申请号：EP13769515.1
申请日：2013-03-28
IPC分类号： A61L31/00 , A61L15/16 , C08G63/06 , C08L101/16
CPC分类号： A61L24/046 , A61L15/26 , A61L15/64 , A61L24/0042 , A61L31/148 , A61L2400/04 , C08L67/025 , C08L67/04 , C08L101/16
摘要： The present invention aims to provide a biodegradable material having an improved biodegradability, an enhanced shape recovery rate after deformation of the material and an improved flexibility. The present invention provides a biodegradable material which is a chemically cross-linked product of: a multivalent compound A having 3 or more functional groups X such as hydroxyl group; a multivalent compound B having 3 or more functional groups Y such as carboxyl group; and a compound C having a structure originated from a hydroxycarboxylic acid whose homopolymer formed by homopolymerization has a glass transition point of -40°C or lower.
摘要翻译： 本发明的目的在于提供一种生物降解性材料，其具有改善的生物降解性，材料变形后的形状恢复率提高和柔韧性提高。 本发明提供一种生物降解性材料，其为以下化学交联产物：具有3个或更多个羟基等官能团X的多价化合物A; 具有3个或更多个官能团Y如羧基的多价化合物B; 以及具有来源于均聚物形成的均聚物的羟基羧酸具有-40℃以下的玻璃化转变点的结构的化合物C.
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8.发明公开BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME 审中-公开生物学家ABBAUBARES TEILCHEN UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP1947137A1
公开(公告)日：2008-07-23
申请号：EP06822401.3
申请日：2006-10-26
CPC分类号： A61L31/148 , A61K9/0019 , A61K9/14 , A61L24/0042 , A61L24/046 , A61L31/06 , A61L2430/36 , C08J3/12 , C08J2367/04 , C08L67/04 , C08L71/02 , C08L2666/22
摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.
摘要翻译： 本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制而成，其能够被携带或注入，而不会在微管直径管（例如主要用于 其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。 作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。
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9.发明公开GRAFT POLYMER AND MOLDINGS THEREOF FOR MEDICAL SUPPLY 失效PFROPFPOLYMERE UND DEREN VERWENDUNG in MEDISINISCHER APPARATUR
公开(公告)号：EP0952168A1
公开(公告)日：1999-10-27
申请号：EP97909734.2
申请日：1997-11-04
发明人： TANAHASHI, Kazuhiro
IPC分类号： C08F291/00 , A61L2/16
CPC分类号： C08F291/00 , A01N25/10 , A01N37/12 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/085 , A61L31/16 , A61L2300/208 , A61L2300/404 , C08F259/04 , C08L33/14 , C08L101/02
摘要： The present invention relates to graft polymer which is characterized in that it is formed by graft polymerization of structural units containing a quaternary ammonium group represented by general formula (A),
(R 2 and R 3 each represent an alkyl group with from 1 to 3 carbons, and R 4 represents an alkyl group with from 3 to 18 carbons. X represents at least one type of ion selected from halogen, sulphate, hydroxide and carboxylic acid ions.),
preferably to graft polymer where the structural units containing a quaternary ammonium group represented by general formula (A) are structural units which are represented by general formula (I),
(R 1 represents at least one species selected from hydrogen, the methyl group and the ethyl group, and n represents an integer in the range 1 to 12. A represents at least one species selected from O, S and NR 5 . R 5 represents hydrogen or an alkyl group with 1 to 12 carbons.) or
graft polymer formed by the graft polymerization of structural units containing a quaternary ammonium group and structural units containing an alkoxypolyalkylene glycol moiety represented by the general formula (B),
-(R 5 O) n R 6 (B)
(n represents an integer in the range 1 to 100. R 5 represents a straight-chain or branched alkylene group with from 1 to 4 carbons, and R 6 represents at least one species selected from hydrogen and straight-chain or branched alkyl groups with from 1 to 4 carbons.).
By applying or incorporating the graft polymer to/in medical devices which are left in the body for a long period, it is possible to prevent microbial infection arising via these medical devices.摘要翻译： 本发明涉及接枝聚合物，其特征在于其通过含有由通式（A）表示的季铵基的结构单元的接枝聚合，
（R2和R3各自表示烷基，从1至 3个碳，R4表示碳原子数为3〜18的烷基，X表示选自卤素，硫酸根，氢氧根和羧酸离子中的至少一种离子），优选为含有季铵的结构单元的接枝聚合物 由通式（A）表示的基团是由通式（I）表示的结构单元， （R 1表示选自氢，甲基和乙基中的至少一种，n表示 A表示选自O，S和NR5中的至少一种，R 5表示氢或具有1至12个碳的烷基）或通过结构单元的接枝聚合形成的接枝聚合物 （B）表示的烷氧基聚亚烷基二醇部分的结构单元， - （R5O）nR6（n表示1〜100的整数。R5表示直链或支链亚烷基 具有1至4个碳，并且R 6表示选自氢和具有1至4个碳的直链或支链烷基中的至少一种。 通过将移植物聚合物施用或并入长时间留在体内的医疗装置中，可以防止通过这些医疗装置产生的微生物感染。 -
公开(公告)号：EP3778716A1
公开(公告)日：2021-02-17
申请号：EP19777608.1
申请日：2019-01-25
IPC分类号： C08G81/00 , A61L17/12 , A61L27/18 , A61L27/34 , A61L27/40 , A61L27/50 , A61L31/06 , A61L31/10
摘要： An object of the present invention is to provide a biodegradable block copolymer having high conformability and excellent degradability. The present invention provides a block copolymer including a polyalkylene glycol block and a polyhydroxyalkanoic acid block, wherein the mass ratio of the polyalkylene glycol block with respect to the total mass is 10 to 60%; the carbonyl carbon has a carbon nuclear relaxation time T1ρ of not more than 20 ms; and the block copolymer satisfies the following Equation 1: χ = χ 1 × χ 2 ≥ 20 [χ 1 : crystallization rate of the polyalkylene glycol block; χ 2 : crystallization rate of a poly-A block, wherein A represents, among the repeat units contained in the polyhydroxyalkanoic acid block, a repeat unit whose homopolymer composed of the same repeat units has a highest crystallization rate].
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