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    SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR
    1.
    发明公开
    SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR 有权
    VERFAHREN ZUR EX-VIVO-ORGAN-FUNKTIONSERHALTUNG MIT LAKTAT ALS INDIKATOR

    公开(公告)号：EP2150105A2

    公开(公告)日：2010-02-10

    申请号：EP08795820.3

    申请日：2008-04-24

    申请人： Transmedics, Inc.

    发明人： HASSANEIN, Waleed ,  KHAYAL, Tamer ,  ELBETANONY, Ahmed ,  LEZBERG, Paul ,  CECERE, Giovanni ,  SOUSA, Dennis ,  HANSEN, Elizabeth

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0247 ,  A01N1/02

    摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

    摘要翻译： 在各种实施例中，本发明提供了与离体器官护理有关的系统，装置和方法。 在某些实施方案中，本发明涉及在近生理条件下离体维持器官。 本申请描述了在器官护理系统心脏灌注装置的动脉和静脉血管中使用乳酸盐测量的方法，以评估：1）孤立心脏的总体灌注状态和2）孤立心脏的代谢状态 和3）分离的供体心脏的整体血管通畅。 本发明的这个方面使用心肌细胞在氧被氧气饥饿时产生/产生乳酸的独特能力的特性，并且当它们被氧充分灌注时代谢/利用乳酸进行能量产生。

    METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS
    4.
    发明公开
    METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS 审中-公开

    公开(公告)号：EP4458152A2

    公开(公告)日：2024-11-06

    申请号：EP24200808.4

    申请日：2008-04-24

    申请人： TransMedics, Inc.

    发明人： HASSANEIN, Waleed ,  KHAYAL, Tamer ,  ELBETANONY, Ahmed ,  LEZBERG, Paul ,  CECERE, Giovanni ,  SOUSA, Dennis ,  HANSEN, Elizabeth

    IPC分类号： A01N1/02

    摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

    SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE AND FOR USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS
    6.
    发明公开
    SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE AND FOR USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS 审中-公开
    用于体外护理和使用乳酸作为指示供体器官状态的系统和方法

    公开(公告)号：EP3251505A1

    公开(公告)日：2017-12-06

    申请号：EP17172411.5

    申请日：2008-04-24

    申请人： Transmedics, Inc.

    发明人： HASSANEIN, Waleed ,  KHAYAL, Tamer ,  ELBETANONY, Ahmed ,  LEZBERG, Paul ,  CECERE, Giovanni ,  SOUSA, Dennis ,  HANSEN, Elizabeth

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0247 ,  A01N1/02

    摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

    摘要翻译： 在各种实施方式中，本发明提供了涉及离体器官护理的系统，装置和方法。 在某些实施方案中，本发明涉及在接近生理条件下维持离体器官。 本申请描述了一种在器官护理系统心脏灌注装置的动脉和静脉血液线路中使用乳酸盐测量的方法，以评估：1）孤立心脏的总体灌注状态和2）孤立心脏的代谢状态 和3）分离的供体心脏的整体血管通畅性。 本发明的这一方面利用心肌细胞独特的能力来产生/产生乳酸，当它们充满氧气时，它们饥饿氧气并代谢/利用乳酸来产生能量。