公开(公告)号：EP1633774B1

公开(公告)日：2010-02-17

申请号：EP04737852.6

申请日：2004-06-18

申请人： Tranzyme Pharma Inc.

发明人： FRASER, Graeme ,  MARSAULT, Eric ,  PETERSON, Mark ,  HOVEYDA, Hamid ,  BEAUBIEN, Sylvie ,  BENAKLI, Kamel ,  DEZIEL, Robert

IPC分类号： C07K5/12 ,  A61K38/06 ,  A61K38/12 ,  C07K5/08 ,  C07K1/113

CPC分类号： C07C213/08 ,  A61K38/12 ,  A61K38/2214 ,  C07C41/18 ,  C07C67/343 ,  C07D273/00 ,  C07D413/06 ,  C07D498/04 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/0827

摘要： The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

摘要翻译： 本发明涉及式（I）的新型大环化合物及其药学上可接受的盐，水合物或溶剂化物：其中R 1，R 2，R 3，R 4，R 5，R 6，n1，m，p Z1，Z2和Z3如 在说明书中描述。 本发明还涉及式（I）化合物，其是胃动素受体的拮抗剂并且可用于治疗与该受体相关的病症并伴有或伴随有运动功能障碍。

公开(公告)号：EP1633774A1

公开(公告)日：2006-03-15

申请号：EP04737852.6

申请日：2004-06-18

申请人： Tranzyme Pharma Inc.

发明人： FRASER, Graeme ,  MARSAULT, Eric ,  PETERSON, Mark ,  HOVEYDA, Hamid ,  BEAUBIEN, Sylvie ,  BENAKLI, Kamel ,  DEZIEL, Robert

IPC分类号： C07K5/12 ,  A61K38/06 ,  A61K38/12 ,  C07K5/08 ,  C07K1/113

CPC分类号： C07C213/08 ,  A61K38/12 ,  A61K38/2214 ,  C07C41/18 ,  C07C67/343 ,  C07D273/00 ,  C07D413/06 ,  C07D498/04 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/0827

摘要： The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.