公开(公告)号：EP3454346A2

公开(公告)日：2019-03-13

申请号：EP18202130.3

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： G21F5/14 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22 ,  G21G1/10 ,  H05H6/00

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.

公开(公告)号：EP3389346B1

公开(公告)日：2020-04-01

申请号：EP18154518.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth, R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J. ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

公开(公告)号：EP3461240A3

公开(公告)日：2019-05-22

申请号：EP18187378.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.

公开(公告)号：EP4216680A1

公开(公告)日：2023-07-26

申请号：EP22207642.4

申请日：2013-04-25

申请人： Triumf Inc.

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.

公开(公告)号：EP3461240A2

公开(公告)日：2019-03-27

申请号：EP18187378.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.

公开(公告)号：EP2841607B1

公开(公告)日：2016-12-28

申请号：EP13781369.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth, R. ,  HANEMAAYER, Victoire ,  MANUELA, Cornelia Hoehr ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J. ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G.

IPC分类号： C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21G1/10 ,  G21K5/08 ,  H05H6/00 ,  B22F9/22 ,  C25D13/22

CPC分类号： G21G1/001 ,  B22F1/0088 ,  B22F7/02 ,  B22F2998/10 ,  B22F2999/00 ,  C25D13/02 ,  C25D13/22 ,  G21G1/10 ,  G21G2001/0042 ,  H05H6/00 ,  B22F9/22 ,  B22F2201/013 ,  B22F3/10

公开(公告)号：EP2841607A1

公开(公告)日：2015-03-04

申请号：EP13781369.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth, R. ,  HANEMAAYER, Victoire ,  MANUELA, Cornelia Hoehr ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J. ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G.

IPC分类号： C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21G1/10 ,  G21K5/08 ,  H05H6/00

CPC分类号： G21G1/001 ,  B22F1/0088 ,  B22F7/02 ,  B22F2998/10 ,  B22F2999/00 ,  C25D13/02 ,  C25D13/22 ,  G21G1/10 ,  G21G2001/0042 ,  H05H6/00 ,  B22F9/22 ,  B22F2201/013 ,  B22F3/10

摘要： A process for producing technetium-99m from a molybdenum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coated with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H
2 O
2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO
4 ] ions thereon and to elute K
2 [MoO
4 ] ions therefrom; (vi) eluting the bound K[TcO
4 ] ions from the resin column; (vii) flowing the eluted K[TcO
4 ] ions through an alumina column to immobilize K[TcO
4 ] ions thereon; (viii) washing the immobilized K[TcO
4 ] ions with water; (ix) eluting the immobilized K[TcO
4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO
4 ] ions.

摘要翻译： 一种由钼-100金属粉末生产锝-99m的方法，包括以下步骤：（i）在基本上无氧的环境中照射由Mo-100金属涂覆的硬化的烧结靶板， 回旋; （ii）用H 2 O 2溶液从被辐照的靶板中溶解钼离子和锝离子以形成氧化物溶液; （iv）将氧化物溶液的pH提高到约14; （v）使经pH调节的氧化物溶液流过树脂柱以在其上固定K [TcO 4]离子并从中洗脱出K 2 [MoO 4]离子; （vi）从树脂柱上洗脱结合的K [TcO 4]离子; （vii）使洗脱的K [TcO 4]离子流过氧化铝柱以固定其上的K [TcO 4]离子; （viii）用水洗涤固定的K [TcO 4]离子; （ix）用盐溶液洗脱固定的K [TcO 4]离子; 和（x）回收洗脱的Na [TcO 4]离子。

公开(公告)号：EP3197246B1

公开(公告)日：2019-09-04

申请号：EP16200459.2

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth, R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J. ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

公开(公告)号：EP3454346A3

公开(公告)日：2019-05-29

申请号：EP18202130.3

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： G21F5/14 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22 ,  G21G1/10 ,  H05H6/00

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.

公开(公告)号：EP3389346A1

公开(公告)日：2018-10-17

申请号：EP18154518.7

申请日：2013-04-25

申请人： Triumf

发明人： SCHAFFER, Paul ,  BENARD, Francois ,  BUCKLEY, Kenneth, R. ,  HANEMAAYER, Victoire ,  KLUG, Julius Alexander ,  KOVACS, Michael S. ,  MORLEY, Thomas J. ,  RUTH, Thomas J. ,  VALLIANT, John ,  ZEISLER, Stefan K. ,  DODD, Maurice G. ,  MANUELA, Cornelia Hoehr

IPC分类号： H05H6/00 ,  G21G1/10 ,  C22B5/18 ,  C22B34/30 ,  C22B9/14 ,  C25D13/02 ,  G21K5/08 ,  C25D13/22 ,  B22F9/22

摘要： A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.