公开(公告)号：EP1495088B1

公开(公告)日：2010-11-10

申请号：EP03720096.1

申请日：2003-04-15

申请人： Tsinghua University ,  CapitalBio Corporation

发明人： YI, Guangshun, Tsinghua University ,  SUN, Baoquan, Tsinghua University ,  CHEN, Depu, Tsinghua University ,  ZHOU, Yuxiang, Tsinghua University ,  CHENG, Jing, Tsinghua University ,  YANG, Wenjun, Tsinghua University ,  GE, Yue, Tsinghua University ,  GUO, Lianghong, Tsinghua University

IPC分类号： C09K11/77 ,  C09K11/61

CPC分类号： C09K11/7772 ,  C09K11/7773 ,  Y10S977/83 ,  Y10S977/834

摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium) = (70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35nm and 200nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.