公开(公告)号：EP1248847A1

公开(公告)日：2002-10-16

申请号：EP01903060.0

申请日：2001-01-12

申请人： Tularik Inc.

发明人： WESCHE, Holger ,  LI, Shyun

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12N5/10 ,  C12Q1/48 ,  A61K38/44 ,  A01K67/027

CPC分类号： C12N9/1205 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2267/03 ,  A01K2267/0368 ,  A61K38/00 ,  C12N15/8509

摘要： The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including IL-1 receptors, IL-18 receptors and LPS receptors. IRAK-4 sequences from human and mouse are provided, as are methods for identifying compounds useful in the treatment or prevention of inflammatory diseases.

公开(公告)号：EP1248847B1

公开(公告)日：2008-03-26

申请号：EP01903060.0

申请日：2001-01-12

申请人： Tularik Inc.

发明人： WESCHE, Holger ,  LI, Shyun

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12N5/10 ,  C12Q1/48 ,  A61K38/44 ,  A01K67/027

CPC分类号： C12N9/1205 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2267/03 ,  A01K2267/0368 ,  A61K38/00 ,  C12N15/8509