公开(公告)号：EP1217700B1

公开(公告)日：2004-10-13

申请号：EP01129143.2

申请日：2001-12-06

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： H01S3/038 ,  H01S3/0975

CPC分类号： H01S3/0315 ,  H01S3/038 ,  H01S3/0818 ,  H01S3/0975

公开(公告)号：EP1470837A3

公开(公告)日：2005-08-10

申请号：EP04252402.5

申请日：2004-04-23

申请人： Tulip, John ,  MOORE, Ronald B. ,  Dickey, Dwayne J.

发明人： Tulip, John ,  MOORE, Ronald B. ,  Dickey, Dwayne J.

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B2017/00057 ,  A61B2018/208 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/0629

摘要： A photodynamic therapy apparatus and method in which (1) phototoxic drug is supplied to the arterical supply of a target tissue, (2) deliver of drug activating light to target tissue through probes is controlled by sequential selection of operation of the probes, (3) an automatic radiance probe is used for efficient optical characterization of target tissue and (4) optical dose is monitored by sequential selection of probes as transmitters and receivers.

公开(公告)号：EP0984267A1

公开(公告)日：2000-03-08

申请号：EP99306913.7

申请日：1999-08-31

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： G01N21/39

CPC分类号： G01N21/39

摘要： A gas detector comprises a laser transmitter (10), a laser receiver (16), and a gas reference cell (26) formed of a sealed encircling wall defining an interior volume. A liquid partially fills the gas reference cell, and a reference gas dissolved in the liquid forms a vapor within the interior volume. At least a portion of the sealed encircling wall is transparent to electromagnetic radiation emitted by the laser transmitter to permit electromagnetic radiation to enter the gas reference cell, traverse a path through the vapor and exit the gas reference cell. The laser transmitter, laser receiver and gas reference cell are coupled together with light guiding elements to form light paths that pass from the laser transmitter to the laser receiver through the gas reference cell and from the laser transmitter to the laser receiver through a target zone. A method of detecting a target gas comprises the steps of directing laser light from the laser transmitter to the laser receiver through a target zone and through the gas reference cell containing a sample of the target gas; detecting light from the laser transmitter that has passed through the target zone and light from the laser transmitter that has passed through the gas reference cell; and analyzing the detected light for the presence of the target gas in the target zone.

摘要翻译： 气体检测器包括激光发射器（10），激光接收器（16）和由限定内部体积的密封环绕壁形成的气体参考单元（26）。 液体部分地填充气体参比单元，并且溶解在液体中的参考气体在内部空间内形成蒸气。 密封的环绕壁的至少一部分对于由激光发射器发射的电磁辐射是透明的，以允许电磁辐射进入气体参考单元，穿过通过蒸气的路径并且离开气体参考单元。 激光发射器，激光接收器和气体参考单元与导光元件耦合在一起以形成光路，其从激光发射器通过气体参考单元从激光发射器传递到激光接收器，并且通过目标区域从激光发射器传递到激光接收器。 检测目标气体的方法包括以下步骤：将来自激光发射器的激光通过目标区域引导到激光接收器，并通过包含目标气体样本的气体参考池; 检测来自已经通过目标区域的激光发射器的光和已经通过气体参考电池的激光发射器的光; 并且对目标区域中目标气体的存在分析检测到的光。

公开(公告)号：EP1470837A2

公开(公告)日：2004-10-27

申请号：EP04252402.5

申请日：2004-04-23

申请人： Tulip, John ,  MOORE, Ronald B. ,  Dickey, Dwayne J.

发明人： Tulip, John ,  MOORE, Ronald B. ,  Dickey, Dwayne J.

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B2017/00057 ,  A61B2018/208 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/0629

摘要： A photodynamic therapy apparatus and method in which (1) phototoxic drug is supplied to the arterical supply of a target tissue, (2) deliver of drug activating light to target tissue through probes is controlled by sequential selection of operation of the probes, (3) an automatic radiance probe is used for efficient optical characterization of target tissue and (4) optical dose is monitored by sequential selection of probes as transmitters and receivers.

摘要翻译： 泵将光毒药物注射到靶组织的动脉供应中，激光（15）用激光束照射靶组织以激活药物。 还包括以下独立权利要求：（1）向靶组织递送药物活化光的装置; 和（2）光剂量监测仪。

公开(公告)号：EP1324051A1

公开(公告)日：2003-07-02

申请号：EP02028357.8

申请日：2002-12-17

申请人： Forrester, Kevin, R. ,  Tulip, John ,  Bray, Robert, C.

发明人： Forrester, Kevin, R. ,  Tulip, John ,  Bray, Robert, C.

IPC分类号： G01P5/00 ,  A61B5/00 ,  A61B5/026

CPC分类号： A61B5/0086 ,  A61B1/042 ,  A61B5/0261

摘要： An endoscopic apparatus for measuring blood flow contained within an enclosed body cavity is claimed. Such apparatus comprises an electromagnetic radiation source (6) for emitting a coherent beam, an optical relay system for propagating the beam down an endoscopic probe to illuminate a target (10) within an enclosed cavity, an endoscopic optical relay system for capturing the reflected light and transmitting an image of the illuminated region onto the surface of a two-dimensional image sensor (1), an analog to digital conversion device for capturing analog output signals from the image sensor for conversion to digital format, a display device for immediate visual display of captured images, a method for calculating flow values from a captured digital image containing speckle structure information of the laser illuminated surface, a memory device for storing digital blood flow images, and a display device for immediate visual display of color coded, blood flow images.

摘要翻译： 要求一种用于测量包含在封闭体腔内的血流的内窥镜装置。 这种设备包括用于发射相干光束的电磁辐射源（6），用于将光束向下传播到内窥镜探针以照亮封闭空腔内的目标（10）的光学继电器系统，用于捕获反射光的内窥镜光学继电器系统 以及将所述照明区域的图像发送到二维图像传感器（1）的表面上，模拟/数字转换装置，用于从用于转换成数字格式的图像传感器捕获模拟输出信号，用于立即视觉显示的显示装置 的捕获图像的方法，用于从包含激光照射表面的斑点结构信息的捕获数字图像计算流量值的方法，用于存储数字血流图像的存储装置和用于立即可视显示彩色编码的血流图像的显示装置 。

公开(公告)号：EP1217700A3

公开(公告)日：2002-12-11

申请号：EP01129143.2

申请日：2001-12-06

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： H01S3/038 ,  H01S3/0975

CPC分类号： H01S3/0315 ,  H01S3/038 ,  H01S3/0818 ,  H01S3/0975

摘要： A large area slab laser, wherein the laser discharge is confined between two large area electrodes (10,12). A two dimensional array of inductors is placed across the electrodes so that the standing wave patterns associated with the propagation of the high frequency driving current are corrected. In one embodiment, the electrodes are planar, in another, the electrodes are annular.

公开(公告)号：EP0275023B1

公开(公告)日：1995-10-04

申请号：EP88100082.2

申请日：1988-01-05

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： H01S3/03

CPC分类号： H01S3/0315 ,  H01S3/2232

公开(公告)号：EP0275023A1

公开(公告)日：1988-07-20

申请号：EP88100082.2

申请日：1988-01-05

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： H01S3/03

CPC分类号： H01S3/0315 ,  H01S3/2232

摘要： A carbon dioxide slab laser (1) includes a pair of cooled metal electrodes (2, 3) disposed to form a gap (6) of less than about 3 millimeters. The electrode surfaces (4, 5) on either side of the gap (6) are polished and highly reflectant. A radio frequency discharge is provided between the electrodes (2, 3) to pass through gas disposed in the gap (6) which is suitable for laser action. Cooling of the gases between the electrodes (2, 3) is achieved by conduction to the metal surfaces of the electrodes (2, 3). Contrary to conventional flowing gas lasers, the two electrodes (2, 3) both reflect and guide the laser light and serve to cool the gas by conduction.

摘要翻译： 二氧化碳板激光器（1）包括设置成形成小于约3毫米的间隙（6）的一对冷却的金属电极（2,3）。 间隙（6）两侧的电极表面（4,5）被抛光并具有高反射率。 在电极（2,3）之间提供射频放电，以通过设置在适于激光作用的间隙（6）中的气体。 通过传导到电极（2,3）的金属表面来实现电极（2,3）之间的气体的冷却。 与传统的流动气体激光器相反，两个电极（2,3）都反射和引导激光，并用于通过传导来冷却气体。

公开(公告)号：EP0984267B1

公开(公告)日：2004-08-04

申请号：EP99306913.7

申请日：1999-08-31

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： G01N21/39

CPC分类号： G01N21/39

公开(公告)号：EP1217700A2

公开(公告)日：2002-06-26

申请号：EP01129143.2

申请日：2001-12-06

申请人： Tulip, John

发明人： Tulip, John

IPC分类号： H01S3/038 ,  H01S3/0975

CPC分类号： H01S3/0315 ,  H01S3/038 ,  H01S3/0818 ,  H01S3/0975

摘要： A large area slab laser, wherein the laser discharge is confined between two large area electrodes (10,12). A two dimensional array of inductors is placed across the electrodes so that the standing wave patterns associated with the propagation of the high frequency driving current are corrected. In one embodiment, the electrodes are planar, in another, the electrodes are annular.

摘要翻译： 大面积板状激光器，其中激光放电被限制在两个大面积电极（10,12）之间。 将电感器的二维阵列放置在电极上，以便校正与高频驱动电流的传播相关联的驻波图案。 在一个实施例中，电极是平面的，而在另一个实施例中，电极是环形的。