公开(公告)号：EP2637713A1

公开(公告)日：2013-09-18

申请号：EP11785876.1

申请日：2011-11-10

申请人： Tyrx, Inc.

发明人： MCJAMES, William ,  DO, Frank ,  GE, Qing ,  PULAPURA, Satish

IPC分类号： A61L31/10 ,  A61L31/16

CPC分类号： A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61N1/059

摘要： An anchorage device 100 comprising a mesh substrate 124 coupled to an implantable medical device 120 is disclosed, where the mesh substrate has a coating 120 comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the device over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.

公开(公告)号：EP2079389B1

公开(公告)日：2018-01-10

申请号：EP07874257.4

申请日：2007-11-06

申请人： Tyrx, Inc.

发明人： BUEVICH, Fatima ,  MOSES, Arikha ,  DO, Frank ,  MCJAMES, William ,  EDELMAN, William ,  DIAMOND, Mason ,  PULAPURA, Satish

IPC分类号： A61L31/14 ,  A61L31/16 ,  A61K31/195 ,  A61K31/445 ,  A61K31/496 ,  A61B50/30

CPC分类号： A61K31/496 ,  A61B50/30 ,  A61B2017/00004 ,  A61B2050/314 ,  A61B2090/0815 ,  A61K31/195 ,  A61K31/445 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61N1/375

摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.

公开(公告)号：EP2079387B1

公开(公告)日：2017-04-12

申请号：EP07873600.6

申请日：2007-11-06

申请人： Tyrx, Inc.

发明人： BUEVICH, Fatima ,  MOSES, Arikha ,  DO, Frank ,  MCJAMES, William ,  EDELMAN, Willam ,  DIAMOND, Mason ,  PULAPURA, Satish ,  TIMOTHY, Shari

IPC分类号： A61F2/00 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61F2/0063 ,  A61F2210/0004 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  A61N1/375 ,  A61N1/3968 ,  C08L23/12 ,  C08L67/04

公开(公告)号：EP2637713B1

公开(公告)日：2016-04-20

申请号：EP11785876.1

申请日：2011-11-10

申请人： Tyrx, Inc.

发明人： MCJAMES, William ,  DO, Frank ,  GE, Qing ,  PULAPURA, Satish

IPC分类号： A61L31/10 ,  A61L31/16

CPC分类号： A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61N1/059