公开(公告)号：EP3705471A1

公开(公告)日：2020-09-09

申请号：EP18872421.5

申请日：2018-11-02

申请人： UBE Industries, Ltd.

发明人： YAMADA, Haruka ,  KOMORI, Ken-ichi ,  SHIRAISHI, Yusuke ,  UMEZAKI, Satoshi ,  KINOSHITA, Naoya ,  ITO, Koji ,  KANDA, Tomoko ,  YONEDA, Kenji ,  TOKUNAGA, Yasunori ,  KIMURA, Tomio

IPC分类号： C07C307/06 ,  A61K31/357 ,  A61P3/04 ,  C07C279/18 ,  C07D321/00

摘要： The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I):

[wherein: A 1 and A 2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A 1 to A 2 ] or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3978073A1

公开(公告)日：2022-04-06

申请号：EP20815167.0

申请日：2020-05-29

申请人： Ube Industries, Ltd.

发明人： KOMORI, Ken-ichi ,  NISHIYAMA, Hayato ,  KINOSHITA, Naoya ,  WADA, Yukinori ,  MORISHITA, Kousuke ,  NINOMIYA, Akishi ,  SHIRAISHI, Yuusuke ,  ONUMA, Kazuhiro ,  OGI, Sayaka ,  KAWADA, Hiroyoshi ,  KIMURA, Tomio

IPC分类号： A61P13/12 ,  A61P43/00 ,  C07D413/10 ,  C07D498/04 ,  A61K31/553

摘要： The present invention provides a compound having Keap1 inhibitory effects and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following general formula (I):

[wherein the symbols have the same meanings as those described in the description] or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.