-
公开(公告)号：EP3214086A1
公开(公告)日：2017-09-06
申请号：EP15855181.2
申请日：2015-10-30
申请人： Ube Industries, Ltd.
发明人： AGA, Yasuhiro , USHIYAMA, Shigeru , IWASE, Noriaki , KONO, Shigeyuki , SUNAMOTO, Hidetoshi , MATSUSHITA, Takashi , OGI, Sayaka , TANAKA, Masayuki , MATOYAMA, Masaaki , UMEZAKI, Satoshi , SHIRAISHI, Yusuke , ONUMA, Kazuhiro , KOJIMA, Masahiro , NISHIYAMA, Hayato , KIMURA, Tomio
CPC分类号： C07F7/10 , A61K31/695 , Y02P20/55
摘要： Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof:
wherein L 1 is an optionally substituted C 1-6 alkylene group or the like, L 2 is a single bond or the like, L 3 is a single bond or the like, R 1 , R 2 , and R 3 are each independently an optionally substituted C 1-4 alkyl group or the like, R 4 is a hydrogen atom or the like, and R 5 is a hydrogen atom or the like.摘要翻译： 提供由式（I）表示的化合物或其药理学上可接受的盐：其中L 1是任选取代的C 1-6亚烷基等，L 2是单键等，L 3是单键等， R1，R2和R3各自独立地为任选取代的C1-4烷基等，R4为氢原子等，R5为氢原子等。
-
公开(公告)号：EP3705471A1
公开(公告)日：2020-09-09
申请号：EP18872421.5
申请日：2018-11-02
申请人： UBE Industries, Ltd.
发明人： YAMADA, Haruka , KOMORI, Ken-ichi , SHIRAISHI, Yusuke , UMEZAKI, Satoshi , KINOSHITA, Naoya , ITO, Koji , KANDA, Tomoko , YONEDA, Kenji , TOKUNAGA, Yasunori , KIMURA, Tomio
IPC分类号： C07C307/06 , A61K31/357 , A61P3/04 , C07C279/18 , C07D321/00
摘要： The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I):
[wherein: A 1 and A 2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A 1 to A 2 ] or a pharmaceutically acceptable salt thereof.
-
搜索结果
2 条记录 (耗时 0.02 秒)
