公开(公告)号：EP1242399A1

公开(公告)日：2002-09-25

申请号：EP00989974.1

申请日：2000-12-14

申请人： UCB S.A.

发明人： STIERNET, Françoise ,  GENICOT, Christophe ,  LASSOIE, Marie-Agnes ,  MOUREAU, Florence ,  RYCKMANS, Thomas ,  TAVERNE, Thierry ,  HENICHART, Jean-Pierre ,  NEUWELS, Michel ,  GOLDSTEIN, Solo

IPC分类号： C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  A61K31/495 ,  A61P11/06 ,  C07D213/36 ,  C07D209/48 ,  C07F9/6509

CPC分类号： C07D295/088 ,  C07D295/13 ,  C07D295/15

摘要： The invention relates to new α-arylethylpiperazine derivatives, which are useful as neurokinin receptor antagonists (NK1antagonists). It also relates to processes for the preparation of said α-arylethylpiperazine derivatives, to their use for the prevention and/or treatment of a condition associated with pathogical levels of substance P in a patient and to pharmaceutical compositions containing them.

公开(公告)号：EP1501801A1

公开(公告)日：2005-02-02

申请号：EP03747411.1

申请日：2003-04-15

申请人： UCB, S.A.

发明人： LASSOIE, Marie-Agnes ,  KNERR, Laurent ,  DEMAUDE, Thierry ,  DE LAVELEYE-DEFAIS, Françoise ,  KOGEJ, Thierry ,  ROUTIER, Sylvain ,  GUILLAUMET, Gerald ,  QUERE, Luc

IPC分类号： C07D215/14 ,  A61K31/47 ,  C07D215/22 ,  C07D401/06 ,  C07D401/12 ,  C07D215/36 ,  C07C233/87 ,  A61P37/08 ,  A61P19/02 ,  A61P29/00 ,  C07C205/49 ,  C07C237/36 ,  C07C43/205 ,  C07C309/65 ,  C07C229/40

CPC分类号： C07C309/65 ,  C07D215/227

摘要： The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.

公开(公告)号：EP1165533B1

公开(公告)日：2004-10-13

申请号：EP00912274.8

申请日：2000-03-23

申请人： UCB, S.A.

发明人： SCANNELl, Ralph ,  CHATELAIN, Pierre ,  TOY-PALMER, Anna ,  DIFFERDING, Edmond ,  ELLIS, James ,  LASSOIE, Marie-Agnes ,  YOUNG, Michelle ,  CAI, Xiong ,  HUSSOIN, Sajjat ,  GREWAL, Gurmit ,  LEWIS, Timothy

IPC分类号： C07D295/00

CPC分类号： C07D295/096 ,  C07D295/084 ,  C07D295/088 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D307/14 ,  C07D307/52 ,  C07D401/04

摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

公开(公告)号：EP1165533A2

公开(公告)日：2002-01-02

申请号：EP00912274.8

申请日：2000-03-23

申请人： UCB, S.A.

发明人： SCANNELl, Ralph ,  CHATELAIN, Pierre ,  TOY-PALMER, Anna ,  DIFFERDING, Edmond ,  ELLIS, James ,  LASSOIE, Marie-Agnes ,  YOUNG, Michelle ,  CAI, Xiong ,  HUSSOIN, Sajjat ,  GREWAL, Gurmit ,  LEWIS, Timothy

IPC分类号： C07D295/00

CPC分类号： C07D295/096 ,  C07D295/084 ,  C07D295/088 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D307/14 ,  C07D307/52 ,  C07D401/04

摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.