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公开(公告)号：EP1434577A1
公开(公告)日：2004-07-07
申请号：EP02800576.7
申请日：2002-09-26
申请人： UCB, S.A.
发明人： ZOU, Dong , DASSE, Olivier , EVANS, Janelle , HIGGINS, Paul , KINTIGH, Jeremy , KNERR, Laurent , KONDRU, Rama , SCHWARTZ, Eric , ZHAI, Hai-Xiao
IPC分类号： A61K31/40 , C07D207/26 , C07D401/04 , C07D405/04 , C07D409/04 , A61P11/06
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
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2.发明公开2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS VLA-4 INHIBITORS 有权2,6-喹啉基和2,6-萘衍生物及其用途FOR VLA-4相关的疾病治疗
公开(公告)号：EP1501801A1
公开(公告)日：2005-02-02
申请号：EP03747411.1
申请日：2003-04-15
申请人： UCB, S.A.
发明人： LASSOIE, Marie-Agnes , KNERR, Laurent , DEMAUDE, Thierry , DE LAVELEYE-DEFAIS, Françoise , KOGEJ, Thierry , ROUTIER, Sylvain , GUILLAUMET, Gerald , QUERE, Luc
IPC分类号： C07D215/14 , A61K31/47 , C07D215/22 , C07D401/06 , C07D401/12 , C07D215/36 , C07C233/87 , A61P37/08 , A61P19/02 , A61P29/00 , C07C205/49 , C07C237/36 , C07C43/205 , C07C309/65 , C07C229/40
CPC分类号： C07C309/65 , C07D215/227
摘要： The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.
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