公开(公告)号：EP3328379A1

公开(公告)日：2018-06-06

申请号：EP16831452.4

申请日：2016-07-29

申请人： UCB Biopharma SPRL

发明人： WRASIDLO, Wolfgang ,  STOCKING, Emily M. ,  HALL, Adrian ,  MACCOSS, Malcolm

IPC分类号： A61K31/404 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12

CPC分类号： C07D417/12 ,  A61P25/28 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08

摘要： The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

公开(公告)号：EP3419975A1

公开(公告)日：2019-01-02

申请号：EP17706753.5

申请日：2017-02-22

申请人： UCB Biopharma SPRL

发明人： DE HARO GARCIA, Teresa ,  LOWE, Martin Alexander ,  MACCOSS, Malcolm ,  TAYLOR, Richard David ,  ZHU, Zhaoning

IPC分类号： C07D417/10 ,  C07D417/14 ,  A61K31/54 ,  A61P33/06

公开(公告)号：EP3380464A1

公开(公告)日：2018-10-03

申请号：EP16800984.3

申请日：2016-11-24

申请人： UCB Biopharma SPRL

发明人： CHARLTON, Rebecca Louise ,  DE HARO GARCIA, Teresa ,  LOWE, Martin Alexander ,  MACCOSS, Malcolm ,  MORGAN, Trevor ,  TAYLOR, Richard David ,  ZHU, Zhaoning

IPC分类号： C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D471/04 ,  A61K31/513 ,  A61P33/06

摘要： A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.