-
公开(公告)号：EP3436460A1
公开(公告)日：2019-02-06
申请号：EP17714785.7
申请日：2017-03-31
申请人： UCB Biopharma SPRL , SANOFI
发明人： DELIGNY, Michaël Louis Robert , HEER, Jag Paul , KEYAERTS, Jean , LÉPISSIER, Luce Elsa , LOWE, Martin Alexander
IPC分类号： C07D487/04 , C07D487/18 , A61K31/428 , A61K31/4188
-
公开(公告)号：EP2872508B1
公开(公告)日：2018-08-29
申请号：EP13739376.5
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： BENTLEY, Jonathan Mark , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , CAIN, Thomas Paul , CHOVATIA, Praful Tulshi , FOLEY, Anne Marie , GALLIMORE, Ellen Olivia , GLEAVE, Laura Jane , HEIFETZ, Alexander , HORSLEY, Helen Tracey , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , JOHNSON, James Andrew , JOHNSTONE, Craig , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LEIGH, Deborah , LOWE, Martin Alexander , MADDEN, James , PORTER, John Robert , QUINCEY, Joanna Rachel , REED, Laura Claire , REUBERSON, James Thomas , RICHARDSON, Anthony John , RICHARDSON, Sarah Emily , SELBY, Matthew Duncan , SHAW, Michael Alan , ZHU, Zhaoning
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
-
公开(公告)号：EP3080126A1
公开(公告)日：2016-10-19
申请号：EP14809008.7
申请日：2014-12-08
申请人： UCB Biopharma SPRL
IPC分类号： C07D473/32 , A61K31/52 , A61P29/00
CPC分类号： C07D473/00 , A61K31/5377 , C07D473/32
摘要： A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
-
公开(公告)号：EP2872508A1
公开(公告)日：2015-05-20
申请号：EP13739376.5
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： BENTLEY, Jonathan Mark , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , CAIN, Thomas Paul , CHOVATIA, Praful Tulshi , FOLEY, Anne Marie , GALLIMORE, Ellen Olivia , GLEAVE, Laura Jane , HEIFETZ, Alexander , HORSLEY, Helen Tracey , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , JOHNSON, James Andrew , JOHNSTONE, Craig , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LEIGH, Deborah , LOWE, Martin Alexander , MADDEN, James , PORTER, John Robert , QUINCEY, Joanna Rachel , REED, Laura Claire , REUBERSON, James Thomas , RICHARDSON, Anthony John , RICHARDSON, Sarah Emily , SELBY, Matthew Duncan , SHAW, Michael Alan , ZHU, Zhaoning
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列式（I）的咪唑并[1,2-a]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。
-
公开(公告)号：EP3080126B1
公开(公告)日：2019-08-28
申请号：EP14809008.7
申请日：2014-12-08
申请人： UCB Biopharma SPRL
IPC分类号： C07D473/32 , A61K31/52 , A61P29/00
-
公开(公告)号：EP3419975A1
公开(公告)日：2019-01-02
申请号：EP17706753.5
申请日：2017-02-22
申请人： UCB Biopharma SPRL
发明人： DE HARO GARCIA, Teresa , LOWE, Martin Alexander , MACCOSS, Malcolm , TAYLOR, Richard David , ZHU, Zhaoning
IPC分类号： C07D417/10 , C07D417/14 , A61K31/54 , A61P33/06
-
公开(公告)号：EP3380464A1
公开(公告)日：2018-10-03
申请号：EP16800984.3
申请日：2016-11-24
申请人： UCB Biopharma SPRL
发明人： CHARLTON, Rebecca Louise , DE HARO GARCIA, Teresa , LOWE, Martin Alexander , MACCOSS, Malcolm , MORGAN, Trevor , TAYLOR, Richard David , ZHU, Zhaoning
IPC分类号： C07D401/10 , C07D403/10 , C07D417/10 , C07D471/04 , A61K31/513 , A61P33/06
摘要： A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.
-
8.发明公开BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY 审中-公开苯并恶嗪酮衍生物及其类似物作为TNF活性调节剂
公开(公告)号：EP3303318A1
公开(公告)日：2018-04-11
申请号：EP16728291.2
申请日：2016-06-07
申请人： UCB Biopharma SPRL
发明人： BRACE, Gareth Neil , CHOVATIA, Prafulkumar Tulshibhai , FOULKES, Gregory , JOHNSON, James Andrew , JONES, Severine Danielle , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LOKE, Pui Leng , LOWE, Martin Alexander , MANDAL, Ajay , NORMAN, Timothy John , PALMER, Christopher Francis , PÉREZ-FUERTES, Yolanda , PORTER, John Robert , SMYTH, Donald , TRANI, Giancarlo , UDDIN, Muhammed , ZHU, Zhaoning
IPC分类号： C07D401/06 , C07D413/06 , C07D498/04 , A61K31/517 , A61K31/519 , A61P29/00
CPC分类号： C07D498/04 , A61K31/423 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/473 , A61K31/538 , A61K31/5383 , A61K31/55 , A61P3/00 , A61P9/00 , A61P23/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D401/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D519/00
摘要： A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
-
9.发明公开TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY 审中-公开四氢吡啶并吡啶衍生物ALS调节剂TNF-AKTIVITÄT
公开(公告)号：EP3080118A1
公开(公告)日：2016-10-19
申请号：EP14811826.8
申请日：2014-12-08
申请人： UCB Biopharma SPRL
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P37/00
摘要： A series of substituted 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 一系列取代的4,5,6,7-四氢-1H-咪唑并[4,5-c]吡啶衍生物，是有效治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.034 秒)
