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1.发明公开FUSED IMIDAZOLE AND PYRAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY 审中-公开CONDENSED咪唑和吡唑衍生物AS TNF活性的调节剂
公开(公告)号：EP3080115A1
公开(公告)日：2016-10-19
申请号：EP14809624.1
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , BENTLEY, Jonathan Mark , BRACE, Gareth Neil , BROOKINGS, Daniel Christopher , CHOVATIA, Praful Tulshi , DEBOVES, Hervé Jean Claude , JOHNSTONE, Craig , JONES, Elizabeth Pearl , KROEPLIEN, Boris , LECOMTE, Fabien Claude , MADDEN, James , MILLER, Craig Adrian , PORTER, John Robert , SELBY, Matthew Duncan , SHAW, Michael Alan , VAIDYA, Darshan Gunvant , YULE, Ian Andrew
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00 , A61P37/00 , A61P43/00
CPC分类号： C07D519/00 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383 , C07D471/04
摘要： A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP3080115B1
公开(公告)日：2019-05-08
申请号：EP14809624.1
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , BENTLEY, Jonathan Mark , BRACE, Gareth Neil , BROOKINGS, Daniel Christopher , CHOVATIA, Praful Tulshi , DEBOVES, Hervé Jean Claude , JOHNSTONE, Craig , JONES, Elizabeth Pearl , KROEPLIEN, Boris , LECOMTE, Fabien Claude , MADDEN, James , MILLER, Craig Adrian , PORTER, John Robert , SELBY, Matthew Duncan , SHAW, Michael Alan , VAIDYA, Darshan Gunvant , YULE, Ian Andrew
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00 , A61P37/00 , A61P43/00
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