专利检索 ap:("UCB FARCHIM, S.A.") AND inv:"ATES, Célal" 第 1 页

1.

发明公开
PIPERAZINE DERIVATIVES AND THEIR USE AS SYNTHESIS INTERMEDIATES 审中-公开
标题翻译：哌嗪衍生物及其作为中间体在合成

公开(公告)号：EP1590323A2

公开(公告)日：2005-11-02

申请号：EP04703367.5

申请日：2004-01-20

申请人： UCB FARCHIM, S.A.

发明人： ATES, Célal , CAVOY, Emile , BOUVY, Didier

IPC分类号： C07D201/00

CPC分类号： C07D271/07 , C07D295/15

摘要： The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

2.

发明公开
PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE 有权
标题翻译： PYROGLUTAMATSALZE和它们在中间体的光学分离FOR DEXTROCETIRIZIN和左西替利的合成

公开(公告)号：EP1858866A1

公开(公告)日：2007-11-28

申请号：EP06707220.7

申请日：2006-02-23

申请人： UCB FARCHIM, S.A.

发明人： PALACIO, Magali , ATES, Célal

IPC分类号： C07D295/088 , C07D207/28

CPC分类号： C07D295/088 , C07D207/28

摘要： The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]- ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide - (R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

3.

发明授权
PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE 有权
标题翻译： PYROGLUTAMATSALZE和它们在中间体的光学分离FOR DEXTROCETIRIZIN和左西替利的合成

公开(公告)号：EP1858866B1

公开(公告)日：2009-06-10

申请号：EP06707220.7

申请日：2006-02-23

申请人： UCB FARCHIM, S.A.

发明人： PALACIO, Magali , ATES, Célal

IPC分类号： C07D295/088 , C07D207/28

CPC分类号： C07D295/088 , C07D207/28

摘要： The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]- ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide - (R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.