FUNCTION MODIFYING NAV 1.7 ANTIBODIES
    1.
    发明公开
    FUNCTION MODIFYING NAV 1.7 ANTIBODIES 审中-公开
    FUNKTIONELLE MODIFIZIERUNG VON NAV1.7-ANTIKÖRPERN

    公开(公告)号:EP2493926A1

    公开(公告)日:2012-09-05

    申请号:EP10770839.8

    申请日:2010-10-27

    申请人: UCB Pharma, S.A.

    IPC分类号: C07K16/28

    摘要: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

    摘要翻译: 结合后的Nav1.7结合实体功能性地修饰离子通道的活性,特别是抗Nav1.7抗体或其结合片段,包含所述抗体的药物组合物,抗体及其组合物在治疗中的用途 ,例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。

    METHOD TO GENERATE ANTIBODIES TO ION CHANNELS
    4.
    发明公开
    METHOD TO GENERATE ANTIBODIES TO ION CHANNELS 审中-公开
    VERFAHREN ZUR ERZEUGUNG VONANTIKÖRPERNGEGENIONENKANÄLE

    公开(公告)号:EP2493927A1

    公开(公告)日:2012-09-05

    申请号:EP10770840.6

    申请日:2010-10-27

    申请人: UCB Pharma, S.A.

    IPC分类号: C07K16/28

    摘要: The present invention provides a method for generating a functionally modifying antibody to an ion channel comprising immunizing a host with a cyclic peptide comprising at least part of an extracellular sequence of said ion channel.

    摘要翻译: 本发明提供了一种产生功能性改变的离子通道抗体的方法,包括用包含至少部分所述离子通道的细胞外序列的环肽免疫宿主。