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公开(公告)号：EP1891101B1
公开(公告)日：2013-05-22
申请号：EP06751903.3
申请日：2006-04-28
申请人： UCB Pharma, S.A. , AMGEN INC.
发明人： PASZTY, Christopher , ROBINSON, Martyn, Kim , GRAHAM, Kevin , HENRY, Alistair, James , HOFFMANN, Kelly, Sue , LATHAM, John , LAWSON, Alastair , LU, Hsieng, Sen , POPPLEWELL, Andy , SHEN, Wenyan , WINKLER, David , WINTERS, Aaron, George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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公开(公告)号：EP3985015A1
公开(公告)日：2022-04-20
申请号：EP21188463.0
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： PASZTY, Christopher , ROBINSON, Martyn Kim , GRAHAM, Kevin , HENRY, Alistair James , HOFFMAN, Kelly Sue , LATHAM, John , LAWSON, Alastair , LU, Hsieng Sen , POPPLEWELL, Andy , SHEN, Wenyan , WINKLER, David , WINTERS, Aaron George
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP3670528A1
公开(公告)日：2020-06-24
申请号：EP19211623.4
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： PASZTY, Christopher , ROBINSON, Martyn Kim , GRAHAM, Kevin , HENRY, Alistair James , HOFFMAN, Kelly Sue , LATHAM, John , LAWSON, Alastair , LU, Hsieng Sen , POPPLEWELL, Andy , SHEN, Wenyan , WINKLER, David , WINTERS, Aaron George
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP1891101A2
公开(公告)日：2008-02-27
申请号：EP06751903.3
申请日：2006-04-28
申请人： UCB Pharma, S.A. , AMGEN INC.
发明人： PASZTY, Christopher , ROBINSON, Martyn, Kim , GRAHAM, Kevin , HENRY, Alistair, James , HOFFMANN, Kelly, Sue , LATHAM, John , LAWSON, Alastair , LU, Hsieng, Sen , POPPLEWELL, Andy , SHEN, Wenyan , WINKLER, David , WINTERS, Aaron, George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白的表位和硬骨素结合剂相关的组合物和方法，例如能够结合硬骨素的抗体。
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公开(公告)号：EP1891100A2
公开(公告)日：2008-02-27
申请号：EP06751835.7
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen Inc.
发明人： LU, Hsieng, Sen , PASZTY, Christopher , ROBINSON, Martyn Kim , HENRY, Alistair James , HOFFMANN, Kelly Sue , LATHAM, John , LAWSON, Alastair , WINKLER, David , WINTERS, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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6.发明授权
公开(公告)号：EP1636270B1
公开(公告)日：2016-07-20
申请号：EP04776553.2
申请日：2004-06-15
申请人： UCB Pharma S.A.
发明人： WINKLER, David, G. , SHI, Jiye , LATHAM, John
IPC分类号： C07K16/22 , A61K39/395 , C07K14/51 , G01N33/53 , A61P19/10
CPC分类号： C07K16/22 , A61K47/643 , A61K47/646 , C07K14/475 , C07K14/51 , C07K16/18 , C07K2317/76 , G01N33/6854 , G01N2333/4704
摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
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公开(公告)号：EP2094731A2
公开(公告)日：2009-09-02
申请号：EP07874263.2
申请日：2007-11-09
申请人： UCB Pharma S.A.
发明人： LATHAM, John , WINKLER, David, G.
IPC分类号： C07K16/22
CPC分类号： C07K16/18 , C07K16/22 , C07K2317/56 , C07K2317/565
摘要： Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
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公开(公告)号：EP1891101B8
公开(公告)日：2013-06-26
申请号：EP06751903.3
申请日：2006-04-28
申请人： AMGEN, INC.
发明人： PASZTY, Christopher , ROBINSON, Martyn, Kim , GRAHAM, Kevin , HENRY, Alistair, James , HOFFMANN, Kelly, Sue , LATHAM, John , LAWSON, Alastair , LU, Hsieng, Sen , POPPLEWELL, Andy , SHEN, Wenyan , WINKLER, David , WINTERS, Aaron, George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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