公开(公告)号：EP0725653B2

公开(公告)日：2008-04-02

申请号：EP94928455.8

申请日：1994-10-04

申请人： UCB Pharma Limited

发明人： ROBERTS, Mark, Medeva Vaccine Res. Unit, Imperial

IPC分类号： A61K39/10

CPC分类号： C07K14/235 ,  A61K39/00

摘要： The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an immune response against B. pertussis infection. The invention also relates to the use of a non-toxic double mutant form of pertussis toxin for the manufacture of an adjuvant composition for stimulating or enhancing a protective immune response of an antigen co-administered therewith. The non-toxic double mutant is preferably one in which the glutamic acid 129 amino acid in the S1 sub-unit has been substituted by glycine and the arginine 9 amino acid has been substituted by lysine.