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公开(公告)号：EP2069781A1
公开(公告)日：2009-06-17
申请号：EP07824351.6
申请日：2007-10-29
申请人： UCL Business PLC
IPC分类号： G01N33/50 , G01N33/579 , A61K35/00
CPC分类号： G01N33/6893 , A61B5/412 , A61B5/4244 , A61B5/7275 , G01N2333/195 , G01N2800/52 , G06F19/00
摘要： A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.
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公开(公告)号：EP3226927A1
公开(公告)日：2017-10-11
申请号：EP15807988.9
申请日：2015-12-02
CPC分类号： A61M1/0218 , A61M1/0094 , A61M1/0259 , A61M1/3486 , A61M1/362 , A61M1/3633 , A61M1/3679 , A61M1/3687 , A61M1/38
摘要： A blood filter device having an iron-chelating molecule, a haem-binding molecule and a haemoglobin-binding molecule bound to a support. Use of the device in a vessel containing blood, for example a blood bag or a flow line, removes haemolysis-derived components from the blood.
摘要翻译： 一种血液过滤装置，具有结合到支持物上的铁螯合分子，血红素结合分子和血红蛋白结合分子。 在装有血液的容器中使用该装置，例如血袋或流动管线，从血液中去除溶血衍生成分。
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公开(公告)号：EP2069781B1
公开(公告)日：2015-12-23
申请号：EP07824351.6
申请日：2007-10-29
申请人： UCL Business PLC
CPC分类号： G01N33/6893 , A61B5/412 , A61B5/4244 , A61B5/7275 , G01N2333/195 , G01N2800/52 , G06F19/00
摘要： A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.
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公开(公告)号：EP2059817B1
公开(公告)日：2010-11-17
申请号：EP07804163.9
申请日：2007-09-07
申请人： UCL Business PLC
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/765 , G01N2800/085
摘要： A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA): albumin ratio (IMAR) in the individual', thereby to assess liver function in the individual.
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公开(公告)号：EP2061533A2
公开(公告)日：2009-05-27
申请号：EP07824370.6
申请日：2007-10-29
申请人： UCL Business PLC
发明人： DAVIES, Nathan , JALAN, Rajiv
IPC分类号： A61M1/34
CPC分类号： A61M1/3496
摘要： The invention provides an apparatus for use in the treatment of an individual suffering from liver disease, including: (a) means for selectively removing albumin from the blood of the individual; and (b) means for selectively removing endotoxin from the blood of the individual.
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公开(公告)号：EP2059817A1
公开(公告)日：2009-05-20
申请号：EP07804163.9
申请日：2007-09-07
申请人： UCL Business PLC
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/765 , G01N2800/085
摘要： A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA): albumin ratio (IMAR) in the individual', thereby to assess liver function in the individual.
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