公开(公告)号：EP3353316A1

公开(公告)日：2018-08-01

申请号：EP16849838.4

申请日：2016-09-26

Applicant: Woundchek Laboratories, Inc.

Inventor： BAYLIFF, Simon ,  BROSNAN, Patrick

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  C12Q1/04 ,  G01N2333/195 ,  G01N2333/948 ,  G01N2333/952 ,  G01N2800/26

Abstract: Methods of detecting a local infection, critical colonization, or infection in a wound, predicting wound healing in a wound, and detecting bacterial pathogenesis in a wound are provided.

公开(公告)号：EP2556164B1

公开(公告)日：2018-05-30

申请号：EP11719662.6

申请日：2011-04-06

Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Biomérieux

Inventor： MOY, Jean-Pierre ,  DUPOY, Mathieu ,  FIGADERE, Olivier ,  PINSTON, Frédéric ,  BOSSY, Geneviève ,  DRAZEK, Laurent ,  GUICHERD, Maryse ,  ROMANENS, Fabien ,  MALLARD, Frédéric

IPC: C12Q1/04 ,  C12Q1/06 ,  C12M1/34 ,  G01B11/24 ,  G01N33/487

CPC classification number: C12Q1/04 ,  C12Q1/06 ,  G01N33/483 ,  G01N2333/195

公开(公告)号：EP3292215A1

公开(公告)日：2018-03-14

申请号：EP16723903.7

申请日：2016-05-06

Applicant: The Procter & Gamble Company

Inventor： HAUGHT, John, Christian ,  XIE, Sancai ,  TANSKY, Cheryl, Sue ,  MANTRI, Yogita, Vinod ,  HUGGINS, Thomas, Glenn ,  WHITE, Donald, James

IPC: C12Q1/68 ,  A61K8/18

CPC classification number: G01N33/566 ,  A61K8/0204 ,  A61K8/21 ,  A61K8/361 ,  A61K8/39 ,  A61K8/42 ,  A61K8/4926 ,  A61K2800/74 ,  A61Q11/00 ,  C12Q1/6897 ,  C12Q2600/136 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5091 ,  G01N33/579 ,  G01N2333/195 ,  G01N2333/705 ,  G01N2333/70596 ,  G01N2400/50

Abstract: Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

公开(公告)号：EP3264990A1

公开(公告)日：2018-01-10

申请号：EP16712067.4

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： BALOG, Júlia ,  KARANCSI, Tamás ,  PRINGLE, Steven Derek ,  TAKÁTS, Zoltán ,  KINROSS, James ,  NICHOLSON, Jeremy K.

IPC: A61B10/02 ,  A61B18/14

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/18 ,  G06F19/324 ,  G06F19/3481 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.

公开(公告)号：EP2561360B1

公开(公告)日：2017-11-08

申请号：EP11772606.7

申请日：2011-04-20

Applicant: DNAE Group Holdings Limited

Inventor： CLARIZIA, Lisa-Jo, Ann ,  ADAMS, Eddie, W. ,  DRYGA, Sergey, A.

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/553

CPC classification number: G01N33/54326 ,  A61B5/055 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2400/043 ,  C07K1/22 ,  C07K16/1267 ,  C12N13/00 ,  C12N15/1013 ,  C12Q1/6806 ,  C12Q1/689 ,  C12Q2565/633 ,  G01N24/08 ,  G01N33/54333 ,  G01N33/56911 ,  G01N2333/195 ,  G01N2446/20 ,  G01R33/465 ,  Y10T428/2982 ,  C12Q2565/629 ,  C12Q2563/143

Abstract: The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.

公开(公告)号：EP3063527A4

公开(公告)日：2017-10-18

申请号：EP14858727

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/06

CPC classification number: G01N15/14 ,  B01L3/502 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2400/086 ,  C12Q1/06 ,  G01N33/493 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2333/195

公开(公告)号：EP2046958B1

公开(公告)日：2016-03-23

申请号：EP07784751.5

申请日：2007-08-03

Applicant: Adelaide Research And Innovation ,  SibTech, Inc.

Inventor： PATON, Adrienne Webster ,  PATON, James Cleland ,  BACKER, Marina V. ,  BACKER, Joseph M.

IPC: C07K14/47 ,  A61K38/00 ,  C07K14/485 ,  C12Q1/37

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/485 ,  C07K2319/00 ,  C12Q1/37 ,  G01N2333/195

公开(公告)号：EP2972354A1

公开(公告)日：2016-01-20

申请号：EP14779477.0

申请日：2014-03-11

Applicant: Geneweave Biosciences Inc.

Inventor： REY, Diego Ariel ,  ROY, Shaunak ,  TEIXEIRA, Leonardo M. ,  GRISWOLD, Ryan C. ,  MATTHEWS, Damian S. ,  OLSON, Kenneth G. ,  RICHARDSON, Bruce J. ,  STELLMACHER, Rick V. ,  YEE, Victor H.

IPC: G01N33/53 ,  G01N33/542 ,  C12P19/34

CPC classification number: C12Q1/6897 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/52 ,  B01L3/523 ,  B01L3/54 ,  B01L3/545 ,  B01L7/00 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2400/0478 ,  B01L2400/06 ,  B01L2400/0683 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01J1/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/13 ,  G01N21/76 ,  G01N21/763 ,  G01N2035/00346 ,  G01N2035/0405 ,  G01N2333/195

Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Abstract translation: 本文描述了使用工程改造的转导颗粒检测和/或鉴定靶细胞（例如细菌）的系统和方法。 在一些实施方案中，一种方法包括将一定量的转导颗粒混合在样品内。 转导颗粒与靶细胞相关联。 转导颗粒是非复制型的，并被工程化以包括配制成使靶细胞产生一系列报道分子的核酸分子。 当样品中存在靶细胞时，保持样品和转导颗粒以表达一系列报告分子。 接收与一定量的报道分子相关的信号。 在一些实施例中，信号的幅度与高于预定量的转导颗粒的数量无关。

公开(公告)号：EP2836610A4

公开(公告)日：2015-12-30

申请号：EP13775260

申请日：2013-04-12

Applicant: ZEUS SCIENTIFIC INC

Inventor： O'HARA SHAWN MARK ,  ZWEITZIG DANIEL

IPC: C12Q1/68 ,  C12Q1/06 ,  C12Q1/18 ,  C12Q1/48 ,  G01N33/02

CPC classification number: C12Q1/485 ,  C12Q1/06 ,  C12Q1/18 ,  C12Q1/48 ,  G01N33/02 ,  G01N2333/195 ,  G01N2333/40 ,  G01N2333/9126 ,  G01N2333/9128 ,  G01N2500/00

公开(公告)号：EP2804953B1

公开(公告)日：2015-10-28

申请号：EP13700708.4

申请日：2013-01-16

Applicant: Centre National de la Recherche Scientifique (CNRS) ,  Universite Paris-Sud

Inventor： DUKAN, Sam ,  DUMONT, Audrey ,  AWWAD, Monzer ,  MALLERON, Annie ,  VAUZEILLES, Boris

IPC: C12Q1/04 ,  G01N33/58

CPC classification number: G01N33/56916 ,  C12Q1/04 ,  C12Q1/10 ,  G01N33/56911 ,  G01N33/582 ,  G01N2333/195 ,  G01N2333/245 ,  G01N2333/255