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1.发明公开THERAPEUTIC USE OF SCIN, A STAPHYLOCOCCAL COMPLEMENT INHIBITOR IN INFLAMMATORY DISEASES 审中-公开SCIN的治疗作用，葡萄球菌补炎症性疾病抑制剂
公开(公告)号：EP1863514A2
公开(公告)日：2007-12-12
申请号：EP06724335.2
申请日：2006-04-03
发明人： ROOIJAKKERS, Suzan, Huberdina, Maria , VAN WAMEL, Willem, Jan, Bastiaan , VAN KESSEL, Cornelis, Petrus, Maria , VAN STRIJP, Johannes, Antonius, Gerardus
CPC分类号： A61K38/164
摘要： The present invention relates to the use of staphylococcal complement inhibitor (SCIN) or a homologue thereof, or a derivate or a fragment of SCIN or the SCIN homologue for the preparation of a medicament for intervening with C3 and C5 convertases. The medicament is in particular intended for inhibiting activation of the classical and/or the alternative pathway of complement. More in particular, the medicament is for treating indications that involve complement activation via the classical and/or alternative parthway.
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2.发明授权THERAPEUTIC USE OF LPI, A STAPHYLOCOCCAL LECTIN PATHWAY INHIBITOR IN INFLAMMATORY DISEASES 有权维生素VERWENDUNG VON LPI，EINEM INHIBITOR DES LECTINWEGS IN STAPHYLOKOKKEN BEIENTZÜNDUNGSKRANKHEITEN
公开(公告)号：EP1641926B1
公开(公告)日：2011-03-16
申请号：EP04740883.6
申请日：2004-07-08
发明人： VAN WAMEL, Willem, Jan, Bastiaan , ROOIJAKKERS, Suzan, Huberdina, Maria , VAN KESSEL, Cornelis, Petrus, Maria , VAN STRIJP, Johannes, Antonius, Gerardus
IPC分类号： A61K39/085 , A61P37/06 , A61K38/16 , A61K48/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53
摘要： The invention relates to nucleic acid molecules encoding (poly)peptides having LPI (Lectin Pathway Inhibitor) activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having LPI activity and to the use of such recombinant (poly)peptides having LPI activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions. In addition the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having LPI activity.
摘要翻译： 本发明涉及编码具有LPI（凝集素途径抑制剂）活性的（多）肽的核酸分子，携带这种分子的重组载体和携带载体的宿主细胞。 本发明还涉及制备具有LPI活性的重组（多）肽以及具有LPI活性的重组（多）肽用于诊断，预防和治疗如治疗炎症反应的方法。 此外，本发明提供包含具有LPI活性的（多）肽作为活性成分的治疗和诊断组合物。
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3.发明公开THERAPEUTIC USE OF LPI, A STAPHYLOCOCCAL LECTIN PATHWAY INHIBITOR IN INFLAMMATORY DISEASES 有权LPI，LECTINWEGS的抑制剂葡萄球菌治疗用途AT点火疾病
公开(公告)号：EP1641926A2
公开(公告)日：2006-04-05
申请号：EP04740883.6
申请日：2004-07-08
发明人： VAN WAMEL, Willem, Jan, Bastiaan , ROOIJAKKERS, Suzan, Huberdina, Maria , VAN KESSEL, Cornelis, Petrus, Maria , VAN STRIJP, Johannes, Antonius, Gerardus
IPC分类号： C12N15/31 , C12N7/01 , C12N15/63 , C07K14/31 , A61K39/085 , A61K48/00 , A61K39/40 , G01N33/569 , C12Q1/68 , A61P29/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53
摘要： The invention relates to nucleic acid molecules encoding (poly)peptides having LPI (Lectin Pathway Inhibitor) activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having LPI activity and to the use of such recombinant (poly)peptides having LPI activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions. In addition the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having LPI activity.
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