公开(公告)号：EP0668909A4

公开(公告)日：1994-09-02

申请号：EP92903512

申请日：1991-12-20

申请人： UNIV ALABAMA RES FOUND

发明人： TOWNES TIM M ,  MCCUNE STEVEN L

IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K38/16 ,  A61P7/08 ,  C07K14/00 ,  C07K14/805 ,  C07K19/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/01 ,  A61K38/00 ,  C07K14/805

摘要： Transgenic, recombinantly cross-linked polymeric human hemoglobins suitable as cell-free blood substitutes have been produced. A plurality of DNA constructs have been designed for efficient expression of modified human hemoglobins in the erythrocytes of the non-human transgenic animals. Substantially pure, non-immunogenic, artificial human hemoglobins are then easily obtained from the erythroid of the transgenic animals.