公开(公告)号：EP1940458A4

公开(公告)日：2010-03-03

申请号：EP06790747

申请日：2006-09-26

申请人： UNIV ALBERTA

发明人： RAJOTTE RAY V ,  BLEACKLEY R CHRIS ,  KORBUTT GREG ,  LORD SARAH J ,  SIPIONE SIMONETTA ,  CARMINE-SIMMEN KATIA ,  GIULIANI FABRIZIO

IPC分类号： A61K38/57 ,  A01K67/027 ,  A61K31/7088 ,  A61K35/14 ,  A61K48/00 ,  A61P37/06

CPC分类号： C07K14/8121 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/108 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/025 ,  A61K31/7088 ,  A61K35/34 ,  A61K35/39 ,  A61K35/60 ,  A61K38/28 ,  A61K48/00 ,  C12N9/6467 ,  C12N15/8509 ,  A61K2300/00

摘要： The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.