公开(公告)号：EP1940458A4

公开(公告)日：2010-03-03

申请号：EP06790747

申请日：2006-09-26

申请人： UNIV ALBERTA

发明人： RAJOTTE RAY V ,  BLEACKLEY R CHRIS ,  KORBUTT GREG ,  LORD SARAH J ,  SIPIONE SIMONETTA ,  CARMINE-SIMMEN KATIA ,  GIULIANI FABRIZIO

IPC分类号： A61K38/57 ,  A01K67/027 ,  A61K31/7088 ,  A61K35/14 ,  A61K48/00 ,  A61P37/06

CPC分类号： C07K14/8121 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/108 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/025 ,  A61K31/7088 ,  A61K35/34 ,  A61K35/39 ,  A61K35/60 ,  A61K38/28 ,  A61K48/00 ,  C12N9/6467 ,  C12N15/8509 ,  A61K2300/00

摘要： The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.

公开(公告)号：EP2473176A4

公开(公告)日：2013-03-06

申请号：EP10813188

申请日：2010-08-20

申请人： UNIV ALBERTA

发明人： SIPIONE SIMONETTA ,  MAGLIONE VITTORIO

IPC分类号： A61K31/7032 ,  A61P25/28 ,  G01N33/68

CPC分类号： A61K31/7032 ,  A61K9/0019 ,  A61K9/0085 ,  G01N33/6896 ,  G01N2800/2835

摘要： Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine stretch in the protein huntingtin (Htt). HD neurons are dysfunctional at multiple levels and have increased susceptibility to stress and apoptotic stimuli. As described therein there is provided compound(s), composition(s), methods and/or kits for the treatment and/or diagnosis of Huntington's disease.