公开(公告)号：EP2214701A4

公开(公告)日：2011-06-01

申请号：EP08843740

申请日：2008-11-03

申请人： UNIV ARKANSAS ,  TEXAS A & M UNIV SYS ,  UNIV GUELPH

发明人： BOTTJE WALTER ,  HARGIS BILLY ,  BERGHMAN LUC ,  KWON YOUNG MIN ,  COLE KIMBERLY ,  COX MANDY ,  LAYTON SHERRYLL ,  EL-ASHRAM SAEED ,  BARTA JOHN ,  TELLEZ GUILLERMO

IPC分类号： A61K39/012 ,  A61K38/04

CPC分类号： A61K39/002 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/455 ,  C07K14/70575 ,  C07K2319/03

摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

公开(公告)号：EP2911676A4

公开(公告)日：2016-10-26

申请号：EP13850423

申请日：2013-10-29

申请人： UNIV ARKANSAS

发明人： HARGIS BILLY M ,  PUMFORD NEIL R ,  MORGAN MARION ,  SHIVARAMAIAH SRICHAITANYA ,  TELLEZ GUILLERMO ,  WOLFENDEN AMANDA

IPC分类号： A61K31/715 ,  A61K31/716 ,  A61K31/722 ,  C07H15/04

CPC分类号： A61K39/39 ,  A61K31/7004 ,  A61K31/722 ,  A61K39/0275 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/6087 ,  A61K2039/62 ,  C08B37/003 ,  C08L5/08 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171

摘要： Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

摘要翻译： 本文提供了包含与醛或甘露糖基化壳聚糖交联的壳聚糖的佐剂。 还提供了制备佐剂的方法和将佐剂与抗原组合或连接的方法。 佐剂 - 抗原组合可以用于疫苗制剂中，并且疫苗制剂可以用于针对抗原来源接种动物或增强受试者的免疫应答的方法。

公开(公告)号：EP2593187A4

公开(公告)日：2014-04-09

申请号：EP11807617

申请日：2011-07-18

申请人： UNIV ARKANSAS

发明人： HARGIS BILLY ,  WOLFENDEN ROSS ,  PUMFORD NEIL R ,  MENCONI ANITA ,  TELLEZ GUILLERMO ,  MORGAN MARION ,  SHIVARAMAIAH SRICHAITANYA ,  WOLFENDEN AMANDA

IPC分类号： A61P31/04 ,  A23K1/00 ,  A23K1/18 ,  A23L1/30 ,  A61K35/74 ,  C12N1/20

CPC分类号： C12N1/20 ,  A23K10/18 ,  A23K40/10 ,  A23K50/75 ,  A23L33/135 ,  A61K35/742

摘要： Methods, compositions and bacterial isolates for improving the gastrointestinal health of animals and in particular of poultry are provided herein. The methods include administering an endospore-forming bacteria to an animal. The bacteria are selected for the ability to reduce the growth and presence of bacterial pathogens, such as Salmonella, Clostridium, and Campylobacter, in the gastrointestinal tract of the animal. The bacteria are also selected for the ability to improve at least one production parameter in the animal.