-
公开(公告)号:EP1073671A4
公开(公告)日:2004-08-18
申请号:EP99919789
申请日:1999-04-23
申请人: UNIV CALIFORNIA
IPC分类号: A61K38/00 , A61K47/48 , C07K14/01 , C07K16/28 , C07K16/32 , C12N15/86 , C07H21/04 , C12N7/00 , C12N7/04 , C12N15/62 , C12N15/63
CPC分类号: C07K14/005 , A61K38/00 , A61K47/6843 , C07K16/2863 , C07K16/2881 , C07K16/32 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/02 , C12N15/86 , C12N2795/14022 , C12N2795/14043 , C12N2795/14045 , C12N2810/859
摘要: This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell.
-
公开(公告)号:EP1071460A4
公开(公告)日:2004-09-08
申请号:EP99919786
申请日:1999-04-23
申请人: UNIV CALIFORNIA
发明人: MARKS JAMES D , POUL MARIE ALIX
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , C07K14/01 , C07K16/28 , C07K16/32 , C07K19/00 , C12N15/86
CPC分类号: A61K47/48823 , A61K9/0019 , A61K31/704 , A61K38/00 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K47/6855 , A61K47/6865 , A61K47/6913 , C07K16/2863 , C07K16/2881 , C07K16/3053 , C07K16/32 , C07K2317/10 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2317/92 , C07K2319/02 , C12N15/86 , C12N2795/10043 , C12N2810/859 , Y10S424/812
-