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    NON-INVASIVE GENE MUTATION DETECTION IN LUNG CANCER PATIENTS
    3.
    发明公开
    NON-INVASIVE GENE MUTATION DETECTION IN LUNG CANCER PATIENTS 审中-公开

    公开(公告)号：EP3152560A4

    公开(公告)日：2018-01-10

    申请号：EP15802964

    申请日：2015-06-03

    申请人： UNIV CALIFORNIA

    发明人： WEI FANG ,  WONG DAVID T W ,  SU WU-CHOU

    IPC分类号： G01N27/327 ,  G01N33/574

    CPC分类号： C12Q1/6825 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N27/3276 ,  G01N33/5438 ,  G01N33/57423

    摘要： A system and method for the detection of saliva biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject. The system includes an electrochemical sensor chip having at least one well, wherein the at least one well contains a working electrode coated with a conducting polymer functionalized with at least one capture probe, and at least one labeled detector probe. When the at least one labeled detector probe is mixed with a sample of the subject containing a biomarker of lung cancer and added to the at least one well, an electric current is applied to the sample, such that when at least some of the biomarker binds to the capture probe, a measurable change in electric current in the sample is created that is indicative of lung cancer.

    SALIVARY MRNA PROFILING, BIOMARKERS, AND RELATED METHODS AND KITS OF PARTS
    4.
    发明公开
    SALIVARY MRNA PROFILING, BIOMARKERS, AND RELATED METHODS AND KITS OF PARTS 有权
    唾液mRNA的配置文件创建，生物标志物和相关的方法和试剂盒-OF-PARTS

    公开(公告)号：EP1730304A4

    公开(公告)日：2007-10-24

    申请号：EP05723309

    申请日：2005-02-17

    申请人： UNIV CALIFORNIA

    发明人： WONG DAVID T W ,  ST JOHN MAIE A R ,  LI YANG

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886

    摘要： A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.