公开(公告)号：EP2841086A4

公开(公告)日：2015-12-02

申请号：EP13775928

申请日：2013-04-09

申请人： UNIV CASE WESTERN RESERVE

发明人： LANG BRADLEY T ,  CREGG JARED M ,  SILVER JERRY ,  WANG YI-LAN

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K38/46 ,  A61P35/00

CPC分类号： A61K38/465 ,  C12Y301/03048

摘要： A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.

摘要翻译： 抑制和/或降低由蛋白多糖诱导的受试者细胞中白细胞共同抗原相关（LAR）家族磷酸酶的活性，信号传导和/或功能的方法包括向细胞施用抑制一种或多种 更多的LAR家族磷酸酶的催化​​活性，信号和功能，而不抑制蛋白聚糖结合或激活LAR家族磷酸酶。