公开(公告)号：EP2392357A4

公开(公告)日：2014-03-26

申请号：EP10735889

申请日：2010-01-29

申请人： UNIV CHUBU EDUCATIONAL FOUNDATION ,  ADVANCED MEDIX INC ,  SAGAWA PRINTING CO LTD

发明人： KOKUBO TADASHI ,  MATSUSHITA TOMIHARU ,  PATTANAYAK DEEPAK K

IPC分类号： A61L27/00 ,  A61F2/28

CPC分类号： A61F2/30767 ,  A61F2002/30838 ,  A61F2002/3084 ,  A61F2310/00023 ,  A61F2310/00616 ,  A61L27/06 ,  A61L2400/18 ,  A61L2430/02

摘要： Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 µm in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 µm in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.