公开(公告)号：EP2392357A4

公开(公告)日：2014-03-26

申请号：EP10735889

申请日：2010-01-29

申请人： UNIV CHUBU EDUCATIONAL FOUNDATION ,  ADVANCED MEDIX INC ,  SAGAWA PRINTING CO LTD

发明人： KOKUBO TADASHI ,  MATSUSHITA TOMIHARU ,  PATTANAYAK DEEPAK K

IPC分类号： A61L27/00 ,  A61F2/28

CPC分类号： A61F2/30767 ,  A61F2002/30838 ,  A61F2002/3084 ,  A61F2310/00023 ,  A61F2310/00616 ,  A61L27/06 ,  A61L2400/18 ,  A61L2430/02

摘要： Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 µm in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 µm in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.

公开(公告)号：EP2014315A4

公开(公告)日：2012-06-20

申请号：EP07736890

申请日：2007-03-16

申请人： SAGAWA PRINTING CO LTD ,  UNIV KYOTO ,  UNIV CHUBU EDUCATIONAL FOUNDATION

发明人： NAKAMURA TAKASHI ,  KOKUBO TADASHI ,  MATSUSHITA TOMIHARU ,  FUJIBAYASHI SHUNSUKE ,  NISHIDA NOBUKATSU

IPC分类号： A61L27/00 ,  A61F2/28

CPC分类号： A61L27/04 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4644 ,  A61F2002/30133 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2230/0015 ,  A61L27/3608

公开(公告)号：EP2058014A4

公开(公告)日：2012-10-24

申请号：EP07805775

申请日：2007-08-28

申请人： JAPAN SCIENCE & TECH AGENCY ,  UNIV CHUBU EDUCATIONAL FOUNDATION ,  ADVANCED MEDIX INC

发明人： KOKUBO TADASHI

IPC分类号： A61L27/00 ,  A61F2/28

CPC分类号： A61L27/06 ,  A61F2/28 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/447 ,  A61F2002/30006 ,  A61F2002/30011 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30156 ,  A61F2002/30271 ,  A61F2002/30593 ,  A61F2002/30787 ,  A61F2002/30843 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/30968 ,  A61F2002/4475 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0023 ,  A61F2230/0082 ,  A61F2250/0015 ,  A61F2250/0023 ,  A61F2310/00023 ,  A61L27/56 ,  A61L2430/02

公开(公告)号：EP2301590A4

公开(公告)日：2013-05-22

申请号：EP09758086

申请日：2009-06-01

申请人： SAGAWA PRINTING CO LTD

发明人： KOKUBO TADASHI ,  KIZUKI TAKASHI ,  YAMAGUCHI SEIJI ,  MATSUSHITA TOMIHARU

IPC分类号： A61L27/06 ,  A61F2/30 ,  A61L27/30

CPC分类号： A61L27/06 ,  A61F2/30767 ,  A61F2310/00023 ,  A61L27/30 ,  A61L2430/02