公开(公告)号：EP2744487A4

公开(公告)日：2015-02-25

申请号：EP12824542

申请日：2012-08-15

申请人： UNIV CITY NEW YORK RES FOUND

发明人： KASHFI KHOSROW ,  KODELA RAVINDER

IPC分类号： A61K31/385 ,  A61P29/00 ,  C07D339/04

CPC分类号： C07C203/04 ,  A61K31/655 ,  C07C327/48 ,  C07C331/28 ,  C07D271/08 ,  C07D339/04 ,  C07D413/12 ,  C07F9/65583 ,  C07F9/6578

摘要： This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.

公开(公告)号：EP2953627A4

公开(公告)日：2017-03-29

申请号：EP14748566

申请日：2014-02-07

申请人： UNIV CITY NEW YORK RES FOUND

发明人： KASHFI KHOSROW ,  CHATTOPADHYAY MITALI ,  KODELA RAVINDER

IPC分类号： A61K31/661

CPC分类号： C07D339/04 ,  C07F9/09 ,  C07F9/091 ,  C07F9/655345 ,  C07F9/65742

摘要： The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof.

摘要翻译： 本发明公开了衍生自NSAIDs的新化合物及其药学上可接受的盐。 本发明的其它方面涉及NSAID衍生物在治疗炎性疾病中的应用及其药物组合物。