专利检索 ap:("UNIV COLORADO STATE RES FOUND") AND inv:"SALMAN MO D" 第 1 页

1.

发明公开
E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS 审中-公开

公开(公告)号：EP3096621A4

公开(公告)日：2017-11-08

申请号：EP15739913

申请日：2015-01-23

申请人： UNIV COLORADO STATE RES FOUND

发明人： LINKE LYNDSEY M , SALMAN MO D , WILUSZ JEFFREY

IPC分类号： A01N63/00 , A61K31/7105 , A61K48/00 , C12N15/11

CPC分类号： C12N15/113 , A01N63/00 , A61K31/7105 , A61K48/0075 , C12N15/1131 , C12N15/70 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2320/32 , C12N2330/51 , C12N2760/16111

摘要： Products and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.