公开(公告)号：EP3256487A4

公开(公告)日：2018-07-18

申请号：EP16749752

申请日：2016-02-09

申请人： UNIV DUKE

发明人： GERSBACH CHARLES A ,  HILTON ISAAC

IPC分类号： C07K14/435 ,  C07K14/315 ,  C12N15/62 ,  C12N15/85

CPC分类号： C12N9/22 ,  C07K2319/80 ,  C12N9/1029 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12Y203/01048

摘要： Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.