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1.发明公开HISTONE DEACETYLASE INHIBITORS IN DIAGNOSIS AND TREATMENT OF THYROID NEOPLASMS 审中-公开组蛋白去乙酰化酶抑制剂的诊断和治疗甲状腺肿瘤
公开(公告)号：EP1356053A2
公开(公告)日：2003-10-29
申请号：EP02718823.4
申请日：2002-01-09
IPC分类号： C12N15/25
CPC分类号： C12N15/1137 , A61K31/00 , A61K38/15 , A61K51/02 , C07K14/705 , C07K14/71 , C12Y203/01048
摘要： Disclosed herein are novel approaches to thyroid cancer therapy. These approaches include methods to enhance thyroid specific gene expression, for example methods to enhance expression of thyroglobulin and/or the Na+/I- symporter in thyroid cancer cells. Enhanced expression of thyroid-specific genes promotes cellular differentiation and reduces biologically aggressive behavior such as invasion and metastasis. In addition, enhanced expression of thyroglobulin and/or the Na+/I- symporter increases the ability of thyroid cancer cells to concentrate iodine or iodide, thereby making the cells more susceptible to radioactive iodine therapy. Also disclosed herein are methods for detecting thyroid neoplasms in a subject, by administering a therapeutically effective amount of a histone deacetylase inhibitor, administering a detectable agent whose uptake or concentration in thyroid cells is increased by administration of the histone deacetylase inhibitor, and detecting the detectable agent.
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公开(公告)号：EP2820127B1
公开(公告)日：2018-09-26
申请号：EP13754523.2
申请日：2013-02-28
发明人： JI, Qingzhou , KREADER, Carol
CPC分类号： C12N9/1029 , C07K14/47 , C07K2319/09 , C07K2319/80 , C07K2319/81 , C07K2319/915 , C12Y203/01048
摘要： The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location.
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公开(公告)号：EP3256487A4
公开(公告)日：2018-07-18
申请号：EP16749752
申请日：2016-02-09
申请人： UNIV DUKE
发明人： GERSBACH CHARLES A , HILTON ISAAC
IPC分类号： C07K14/435 , C07K14/315 , C12N15/62 , C12N15/85
CPC分类号： C12N9/22 , C07K2319/80 , C12N9/1029 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12Y203/01048
摘要： Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
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公开(公告)号：EP3256487A2
公开(公告)日：2017-12-20
申请号：EP16749752.8
申请日：2016-02-09
申请人： Duke University
IPC分类号： C07K14/435 , C07K14/315 , C12N15/62 , C12N15/85
CPC分类号： C12N9/22 , C07K2319/80 , C12N9/1029 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12Y203/01048
摘要： Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
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公开(公告)号：EP1528928B1
公开(公告)日：2010-07-21
申请号：EP03717515.5
申请日：2003-04-28
发明人： BEN-NERIAH, Yinon , ALKALAY, Irit , AMIT, Sharon , BIRMAN, Yaara , HATZUBAI, Ada
CPC分类号： A61K38/18 , A61K31/35 , A61K38/1709 , A61K38/45 , A61K38/465 , C12Y203/01048 , C12Y301/03016
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公开(公告)号：EP1528928A2
公开(公告)日：2005-05-11
申请号：EP03717515.5
申请日：2003-04-28
发明人： BEN-NERIAH, Yinon , ALKALAY, Irit , AMIT, Sharon , BIRMAN, Yaara , HATZUBAI, Ada
CPC分类号： A61K38/18 , A61K31/35 , A61K38/1709 , A61K38/45 , A61K38/465 , C12Y203/01048 , C12Y301/03016
摘要： The present invention provides modulators of β-catenin phosphorylation. More specifically, the present invention provides inhibitors and enhancers of β-catenin Serine 45 (S45) phosphorylation. Examples of inhibitors provided by the invention are the proteins Dishevelled (Dvl), Wnt, phosphatase PP2A and CKI7. Examples of enhancers of beta-catenin phosphorylation are phosphatase inhibitors and proteins that promote -catenin acetylation, like FRAT1. In addition, the present invention provides compositions and uses of the modulators of the invention, specifically for the treatment of cancer, as well as a method for screening such modulators.
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公开(公告)号：EP2820127A1
公开(公告)日：2015-01-07
申请号：EP13754523.2
申请日：2013-02-28
发明人： JI, Qingzhou , KREADER, Carol
CPC分类号： C12N9/1029 , C07K14/47 , C07K2319/09 , C07K2319/80 , C07K2319/81 , C07K2319/915 , C12Y203/01048
摘要： The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location.
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8.发明授权CONTROL OF GENE EXPRESSION USING A COMPLEX OF AN OLIGONUCLEOTIDE AND A REGULATORY PEPTIDE 有权基因表达的使用寡核苷酸组成的复合物和调节肽CONTROL
公开(公告)号：EP1470226B1
公开(公告)日：2007-08-01
申请号：EP02801387.8
申请日：2002-10-11
发明人： HART, Stephen Div. of Medicine, Cancer Cell Bio. Sect. , ALI, Simak Div. of Medicine, Cancer Cell Bio. Sect. , PUFONG, Boris, Tumi Cyprotex Discovery Ltd , PORTER, Andrew, Christopher, George MRC Clinical , BULUWELA, Laki Div. of Medicine, Cancer Cell Bio. , VAINIKKA, Satu , JENKINSON, John, David Cancer Research Technology Ltd , KANDA, Patrick Activotec-SSP, Ltd., Biomedical Sc
IPC分类号： C12N15/11 , C07K14/47 , C12N15/67 , A61K38/16 , A61K47/48 , C12N5/10 , A01K67/027 , C12N15/82
CPC分类号： C12N15/113 , A61K38/00 , C07K2319/00 , C12N9/16 , C12N15/63 , C12N2310/15 , C12N2310/3513 , C12Y203/01048
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
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公开(公告)号：EP1243290A3
公开(公告)日：2004-03-17
申请号：EP02014371.5
申请日：1999-10-19
申请人： Methylgene, Inc.
CPC分类号： C12N15/1137 , A61K38/00 , A61K45/06 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12Y201/01045 , C12Y203/01048 , C12N2310/3521
摘要： The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.
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公开(公告)号：EP1243289A3
公开(公告)日：2004-03-17
申请号：EP02014370.7
申请日：1999-10-19
申请人： Methylgene, Inc.
CPC分类号： C12N15/1137 , A61K38/00 , A61K45/06 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12Y201/01045 , C12Y203/01048 , C12N2310/3521
摘要： The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.
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