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公开(公告)号:EP1667714A4
公开(公告)日:2008-09-24
申请号:EP04784298
申请日:2004-09-17
发明人: HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号: A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译: 本发明一般涉及免疫原,特别涉及用于诱导中和大范围的HIV原代分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。