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公开(公告)号：EP1917040A4
公开(公告)日：2012-12-12
申请号：EP06802155
申请日：2006-08-23
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
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公开(公告)号：EP1667714A4
公开(公告)日：2008-09-24
申请号：EP04784298
申请日：2004-09-17
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV原代分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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公开(公告)号：EP2318430A4
公开(公告)日：2012-08-29
申请号：EP09806982
申请日：2009-08-14
发明人： KORBER BETTE T , FISCHER WILLIAM , LETVIN NORMAN , LIAO HUA-XIN , HAYNES BARTON F , HAHN BEATRICE H
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
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公开(公告)号：EP2129395A4
公开(公告)日：2012-05-09
申请号：EP08799657
申请日：2008-03-27
申请人： UNIV CALIFORNIA , UNIV DUKE , UNIV ALABAMA , UNIV NORTH CAROLINA
发明人： HAYNES BARTON F , KORBER BETTE T , HAHN BEATRICE H , BHATTACHARYA TANMOY , GNANAKARAN GNANA S , GAO FENG , SWANSTROM RON , SHAW GEORGE
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134
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公开(公告)号：EP3126502A4
公开(公告)日：2018-01-17
申请号：EP15772335
申请日：2015-03-31
IPC分类号： C12N15/49 , A61K31/7088 , A61K39/21 , C07K14/155
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
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公开(公告)号：EP2895500A4
公开(公告)日：2016-04-13
申请号：EP13837551
申请日：2013-09-12
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , UNIV PENNSYLVANIA , UNIV BOSTON , US GOV HEALTH & HUMAN SERV , UNIV LELAND STANFORD JUNIOR
发明人： HAYNES BARTON F , LIAO HUA-XIN , LYNCH REBECCA M , ZHOU TONGQING , GAO FENG , BOYD SCOTT , SHAW GEORGE M , HAHN BEATRICE H , KEPLER THOMAS B , KORBER BETTE T , KWONG PETER , MASCOLA JOHN
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
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公开(公告)号：EP2542566A4
公开(公告)日：2013-09-11
申请号：EP11751024
申请日：2011-03-03
发明人： SHAW GEORGE M , HAHN BEATRICE H , LI HUI , HAYNES BARTON F , MARKOWITZ MARTIN
CPC分类号： A61K39/21 , A61K39/12 , C12N7/00 , C12N2740/16021 , C12N2740/16034
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