公开(公告)号：EP3139922A4

公开(公告)日：2017-12-27

申请号：EP15788649

申请日：2015-05-05

申请人： UNIV EMORY

发明人： RENGARAJAN JYOTHI ,  ADEKAMBI TOIDI ,  IBEGBU CHRISTIAN C

IPC分类号： A61K31/44 ,  A61K31/495 ,  A61K31/4965 ,  A61P31/06

CPC分类号： G01N33/56972 ,  A61K31/133 ,  A61K31/4409 ,  A61K31/496 ,  A61K31/4965 ,  A61K45/06 ,  G01N33/5091 ,  G01N2333/35 ,  G01N2333/47 ,  G01N2333/57 ,  G01N2333/70514 ,  G01N2333/70539 ,  G01N2333/70596 ,  G01N2800/26 ,  A61K2300/00

摘要： This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments, the disclosure relates to methods of treatment of a subject diagnosed with tuberculosis comprising the steps of, measuring a pool of CD4 IFN-γ cells for cells that also express CD38, HLA-DR, and/or Ki-67 providing a measurement; associating an increased measurement of CD4 IFN-γ cells that also express CD38, HLA-DR, Ki-67, compared to a control, as an indication that the subject has active tuberculosis; and treating the subject with an aggressive tuberculosis treatment.