公开(公告)号：EP3212658A4

公开(公告)日：2018-07-25

申请号：EP15855176

申请日：2015-10-30

申请人： COCRYSTAL PHARMA INC ,  UNIV EMORY

发明人： COATS STEVEN J ,  AMBLARD FRANCK ,  GARNIER-AMBLARD ETHEL ,  SCHINAZI RAYMOND F

IPC分类号： C07H19/10 ,  A61K31/712 ,  A61K38/21 ,  A61P31/12 ,  A61P35/00 ,  C07H19/067 ,  C07H19/167 ,  C07H19/20

CPC分类号： C07H19/10 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/712 ,  A61K38/21 ,  A61K45/06 ,  C07B59/005 ,  C07B2200/05 ,  C07H19/06 ,  C07H19/16 ,  C07H19/20 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  A61K2300/00

摘要： The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya Ebola and West Nile virus), RSV, HEV, and influenza infection and cancer in human subjects or other animal hosts.

公开(公告)号：EP3179916A4

公开(公告)日：2018-03-14

申请号：EP15832416

申请日：2015-08-14

申请人： UNIV EMORY ,  GEORGIA TECH RES CORPORATION

发明人： LAM WILBUR A ,  TYBURSKI ERIKA A ,  STOY WILLIAM A ,  WEISS ALEXANDER J

IPC分类号： A61B5/15 ,  A61B5/157 ,  B01L3/00 ,  G01N33/48 ,  G01N33/72 ,  G06T7/00 ,  G06T7/90

CPC分类号： G01N33/726 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/157 ,  B01L3/502 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0672 ,  B01L2300/168 ,  G01N33/721 ,  G01N2333/805 ,  G06T7/0012 ,  G06T7/90

摘要： Diagnostic devices; systems, methods and computer-readable media store instructions related to determining hemoglobin information using those devices. The methods may include processing a captured image of the reservoir and/or device and the device information to determine color information for the solution and the scale, the color information including one or more color attributes; adjusting the color information for the solution based on the color information for the scale; and determining hemoglobin information (e.g., hemoglobin level, disease state and/or calculated hematocrit) based on the adjusted color information and a stored profile information associated with the device information.

公开(公告)号：EP3139922A4

公开(公告)日：2017-12-27

申请号：EP15788649

申请日：2015-05-05

申请人： UNIV EMORY

发明人： RENGARAJAN JYOTHI ,  ADEKAMBI TOIDI ,  IBEGBU CHRISTIAN C

IPC分类号： A61K31/44 ,  A61K31/495 ,  A61K31/4965 ,  A61P31/06

CPC分类号： G01N33/56972 ,  A61K31/133 ,  A61K31/4409 ,  A61K31/496 ,  A61K31/4965 ,  A61K45/06 ,  G01N33/5091 ,  G01N2333/35 ,  G01N2333/47 ,  G01N2333/57 ,  G01N2333/70514 ,  G01N2333/70539 ,  G01N2333/70596 ,  G01N2800/26 ,  A61K2300/00

摘要： This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments, the disclosure relates to methods of treatment of a subject diagnosed with tuberculosis comprising the steps of, measuring a pool of CD4 IFN-γ cells for cells that also express CD38, HLA-DR, and/or Ki-67 providing a measurement; associating an increased measurement of CD4 IFN-γ cells that also express CD38, HLA-DR, Ki-67, compared to a control, as an indication that the subject has active tuberculosis; and treating the subject with an aggressive tuberculosis treatment.

公开(公告)号：EP3134423A4

公开(公告)日：2017-11-29

申请号：EP15783296

申请日：2015-04-24

申请人： COCRYSTAL PHARMA INC ,  UNIV EMORY

发明人： COATS STEVEN J ,  ZHOU SHAOMAN ,  AMBLARD FRANCK ,  SCHINAZI RAYMOND F ,  KHALIL AHMED

IPC分类号： C07H19/06 ,  A61K31/7068 ,  A61K31/7076 ,  A61P31/12 ,  A61P31/16 ,  A61P35/00 ,  C07D487/04 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/16 ,  C07H19/207

CPC分类号： C07H19/207 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K45/06 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/16 ,  A61K2300/00

摘要： The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile virus), RSV and influenza infection and cancer in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.

公开(公告)号：EP3137074A4

公开(公告)日：2017-11-15

申请号：EP15785214

申请日：2015-04-17

申请人： UNIV EMORY

发明人： GANESH THOTA ,  JIANG JIANXIONG ,  DINGLEDINE RAY J

IPC分类号： A61K31/404 ,  A61K31/4045 ,  A61K31/506 ,  A61P25/00 ,  A61P29/00

CPC分类号： A61K31/551 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06

摘要： The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflamation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

公开(公告)号：EP3129361A4

公开(公告)日：2017-11-15

申请号：EP15777056

申请日：2015-04-08

申请人： UNIV EMORY

发明人： YE KEQIANG ,  FU HAIAN ,  DU YUHONG

IPC分类号： A61K31/4245 ,  A61K9/20 ,  A61K9/48 ,  A61K31/4015 ,  A61K31/426 ,  A61K31/433 ,  A61K31/47 ,  A61K31/496 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5377 ,  A61K47/38 ,  A61P25/16 ,  A61P25/28 ,  C07D271/12 ,  C07D285/14

CPC分类号： C07D271/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/4015 ,  A61K31/426 ,  A61K31/433 ,  A61K31/47 ,  A61K31/496 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5377 ,  C07D271/02 ,  C07D471/04 ,  C07D473/04

摘要： This disclosure relates to asparagine endopeptidase inhibitors and compositions and uses related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are useful for treating or preventing neurodegenerative diseases and cognitive disorders such as Alzheimer's Disease. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient. In certain embodiments, the disclosure relates to methods of treating or preventing a neurodegenerative disease comprising administering an effective amount of pharmaceutical composition a asparagine endopeptidase inhibitor disclosed herein to a subject in need thereof.

公开(公告)号：EP3105333A4

公开(公告)日：2017-08-02

申请号：EP15746077

申请日：2015-02-09

申请人： UNIV EMORY ,  CHILDREN'S HEALTHCARE OF ATLANTA INC

发明人： SPENCER H TRENT ,  DOERING CHRISTOPHER B ,  HERRIN BRANTLEY R ,  COOPER MAX DALE

IPC分类号： C12N15/63 ,  C07K14/54 ,  C07K14/705 ,  C07K19/00 ,  C12N5/0783 ,  C12N9/02 ,  C12N9/10

CPC分类号： C07K14/70521 ,  A61K35/17 ,  A61K38/00 ,  A61K45/06 ,  A61K2035/124 ,  C07K14/461 ,  C07K14/70503 ,  C07K14/7051 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/70 ,  C12N15/85

摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.

摘要翻译： 本公开涉及具有衍生自淋巴细胞受体的肽序列的嵌合蛋白的重组细胞表达以及用于治疗癌症的用途。 在某些实施方案中，本公开涉及包含编码嵌合蛋白的核酸的重组载体，所述嵌合蛋白具有基于能够结合肿瘤相关抗原的可变淋巴细胞受体（VLR）和具有T细胞的节段的靶向部分的节段 信号转导亚基。 在某些实施方案中，重组载体用于基于免疫的癌症治疗。

公开(公告)号：EP3043803A4

公开(公告)日：2017-03-29

申请号：EP14844012

申请日：2014-09-10

申请人： UNIV EMORY

发明人： LIOTTA DENNIS C ,  PAINTER GEORGE R ,  BLUEMLING GREGORY R ,  DE LA ROSA ABEL

IPC分类号： A61K31/7068 ,  A61K31/706 ,  A61P31/14 ,  C07H19/06

CPC分类号： A61K31/7068 ,  A61K9/127 ,  A61K45/06 ,  C07H19/06 ,  C07H19/10 ,  A61K2300/00

摘要： This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

摘要翻译： 本公开涉及核苷酸和核苷治疗组合物和用于治疗感染性疾病，病毒感染和癌症的用途，其中核苷酸或核苷的碱基含有至少一种硫醇，硫酮或硫醚。

公开(公告)号：EP2943904A4

公开(公告)日：2016-09-07

申请号：EP14737727

申请日：2014-01-10

申请人： UNIV EMORY ,  GEORGIA TECH RES INST

发明人： DOETSCH PAUL W ,  HUNT WILLIAM D ,  SHIN DONG MOON ,  MORENO CARLOS SANCHEZ ,  CHEN GEORGIA ZHUO

IPC分类号： G06F19/10 ,  G01N33/48 ,  G01N33/53 ,  G01N33/68 ,  G06F19/28

CPC分类号： G06F19/28 ,  G01N33/68 ,  G01N33/6887 ,  G01N2333/4712

摘要： Methods, systems, and computer readable storage media relate to processing and analyzing a sample to determine presence or concentration of at least one sensor target in a sample. A method of quantifying a sample using a sensor may include obtaining sensor data, the sensor data including in-situ calibration data from a housekeeping protein; analyzing the sensor data; and outputting results of the analyzing. The method may be used with a system that includes a sensing device and a module. The system may also include an analysis device that can be in communication with the sensing device.

公开(公告)号：EP2956131A4

公开(公告)日：2016-08-24

申请号：EP14751072

申请日：2014-02-14

申请人： YOUR ENERGY SYSTEMS LLC ,  UNIV EMORY ,  CHILDRENS HEALTHCARE ATLANTA INC

发明人： BROWN LOU ANN ,  GUILFORD FREDERICK TIMOTHY

IPC分类号： A61K9/127 ,  A61K38/06

CPC分类号： A61K38/063 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/0095 ,  A61K9/127 ,  A61K9/4858

摘要： The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as demonstrated by efficacy in reducing by large multiples the presence of cultures of Klebsiella in rats in animal tests. Further, because the liposomal glutathione bolsters body defenses as well as appearing to have direct killing action, the propensity to create more and more resistant strains to antibiotic treatment is downgraded.