公开(公告)号：EP1806377A4

公开(公告)日：2008-04-23

申请号：EP05795884

申请日：2005-10-20

申请人： UNIV GUNMA NAT UNIV CORP

发明人： OKU HIROYUKI ,  SHICHIRI KAZUAKI ,  TAIRA TOMOHIRO ,  INOUE AYA ,  YAMADA KEIICHI ,  KATAKAI RYOICHI

IPC分类号： C08G63/06 ,  A61K47/42 ,  C07K11/00 ,  C07K14/00 ,  C08G69/44

CPC分类号： C08G63/6852 ,  A61K47/42 ,  C07K11/00

摘要： There is provided a temperature responsive polymer compound which comprises a repeating unit represented by the following general formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ-R 1 -Hmb-R 2 -€ƒ€ƒ€ƒ€ƒ€ƒ(I) where, Hmb represents a valic acid residue represented by the following formula (II); R 1 represents an amino acid, a polypeptide, or a hydroxy acid being linked by ester bond; R 2 represents an amino acid or a polypeptide being linked by amide bond or a hydroxy acid being linked by ester bond: and wherein said polymer compound has 18 or more of amino acids residues and hydroxy acid residues in total.

摘要翻译： 具有下述通式（I）所示的重复单元的温度响应性聚合物：-R

公开(公告)号：EP2058324A4

公开(公告)日：2010-10-13

申请号：EP07792365

申请日：2007-08-10

申请人： UNIV GUNMA NAT UNIV CORP

发明人： OKU HIROYUKI ,  SHIMODA YUYA ,  INOUE AYA ,  TAKAYAMA CHIE ,  YAMADA KEIICHI ,  KATAKAI RYOICHI

IPC分类号： C07K11/00

CPC分类号： C07K11/02 ,  A61K38/00 ,  C07K11/00

公开(公告)号：EP1803731A4

公开(公告)日：2011-01-26

申请号：EP05788001

申请日：2005-09-28

申请人： UNIV GUNMA NAT UNIV CORP

发明人： OKU HIROYUKI ,  OMI KAZUTO ,  KURIYAMA KEISUKE ,  YAMAMOTO JYUNYA ,  YAMADA KEIICHI ,  KATAKAI RYOICHI ,  SATO KUMIKO ,  SUZUKI MAMORU ,  KAWAZU SHIN-ICHIRO ,  KANO SHIGEYUKI

IPC分类号： C07K14/445 ,  A61K39/002 ,  A61K39/385 ,  A61P33/06 ,  C07K1/06 ,  C07K1/10 ,  G01N33/531 ,  G01N33/569

CPC分类号： G01N33/56905 ,  A61K39/00 ,  C07K14/445 ,  C12N9/88

摘要： The peptide production method of the present invention produces a peptide (SEQ ID NO: 1) of a protein from Plasmodium falciparum, which is effective as a malaria vaccine. The method produces the peptide of SEQ ID NO: 1 by linking the fragments (i) through (v) shown below: (v) Asn-Asn-Asp-Xaa (SEQ ID NO: 2); (iv) Asp-Phe-Lys-Thr-Pro (SEQ ID NO: 3); (iii) Asn-Lys-Thr-Tyr-Asp-Leu (SEQ ID NO: 4); (ii) Phe-Tyr-Asn-Ser-Glu (SEQ ID NO: 5); and (i) Xaa-Ala-Ser-Glu (SEQ ID NO: 6), where 'Xaa' in (i) and (v) represents zero or any arbitrary number of amino acid residues.