公开(公告)号：EP2889307A4

公开(公告)日：2016-04-13

申请号：EP13828357

申请日：2013-06-18

申请人： UNIV HAINAN

发明人： LUO SULAN ,  ZHANGSUN DONGTING ,  WU YONG ,  ZHU XIAOPENG ,  HU YUANYAN ,  BING HUI ,  MCINTOSH J MICHAEL

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61K38/17 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P25/34 ,  A61P25/36 ,  A61P29/00 ,  C07K1/04 ,  C07K1/06 ,  C07K1/16 ,  C07K14/435 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/43504 ,  A61K38/00 ,  C07K1/061 ,  C07K1/16 ,  C07K1/30 ,  C07K2319/00 ,  G01N33/5032 ,  G01N33/944 ,  G01N2333/70571 ,  G01N2500/04

摘要： The present invention provides a novel ±-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The ±-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as ±3²2 nAChRs, ±6/±3²2²3 nAChR or ±3²4 nAChR or ±6/±3²4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

公开(公告)号：EP2889308A4

公开(公告)日：2015-12-09

申请号：EP13804082

申请日：2013-06-08

申请人： UNIV HAINAN

发明人： LUO SULAN ,  ZHANGSUN DONGTING ,  WU YONG ,  ZHU XIAOPENG ,  HU YUANYAN ,  MCINTOSH J MICHAEL

IPC分类号： C07K14/435 ,  A61K38/17 ,  C12N15/12

CPC分类号： C07K14/43504 ,  A61K38/00 ,  C07K1/00 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/55 ,  G01N33/5041 ,  G01N33/6872 ,  G01N33/944 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention pertains to fields of biochemistry and molecular biology, relates to an ±O-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof. The present invention further relates to a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The new ±O-superfamily conotoxin peptide of the present invention is capable of specifically blocking acetylcholine receptor (nAChRs) (e.g., ±9±10 nAChR), and NMDA receptor (e.g., NR2C NMDAR), and has activity for treatment of neuralgia, addiction, and activity for treatment of chemotherapy of cancers, breast cancer, lung cancer, wound healing, epilepsia, ischemia, and thus is promising in the manufacture of analgesic, a medicament for treatment of addiction, and a tool drug for neuroscience.