公开(公告)号：EP2984184A4

公开(公告)日：2016-11-30

申请号：EP14783210

申请日：2014-04-08

申请人： UNIV ILLINOIS ,  UNIV TEXAS

发明人： HERGENROTHER PAUL J ,  BOOTHMAN DAVID A ,  BAIR JOSEPH S ,  CAO LIFEN ,  GAO JIMMING ,  HUANG XIUMEI ,  LUO XIUQUAN ,  MA XINPENG ,  MOORE ZACHARY R ,  PARKINSON ELIZABETH I

IPC分类号： A61K31/353 ,  A61K31/131 ,  A61K31/352 ,  A61K31/4738 ,  A61K31/4745 ,  A61K31/706 ,  A61K45/06 ,  A61P35/00 ,  C12Q1/68

CPC分类号： A61K31/706 ,  A61K31/131 ,  A61K31/353 ,  A61K31/4738 ,  A61K31/4745 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61K2300/00

摘要： The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.