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    COMPOSITION FOR INHIBITING THE ONSET OF ARTERIOSCLEROSIS AND INHIBITION METHOD
    4.
    发明公开
    COMPOSITION FOR INHIBITING THE ONSET OF ARTERIOSCLEROSIS AND INHIBITION METHOD 有权
    ZUSAMMENSETZUNG ZUR HEMMUNG DES EINSETZENS VON ARTERIOSKLEROSE UND HEMMVERFAHREN

    公开(公告)号：EP1757297A4

    公开(公告)日：2007-10-31

    申请号：EP05743564

    申请日：2005-05-26

    申请人： UNIV KAGAWA NAT UNIV CORP

    发明人： TOKUDA MASAAKI ,  MURAO KOUJI ,  ISHIDA TOSHIHIKO ,  IZUMORI KEN

    IPC分类号： A61K31/7004 ,  A23K1/16 ,  A23L1/30 ,  A61P9/10 ,  A61P43/00 ,  C07H3/02

    CPC分类号： A23K20/163 ,  A23L33/10 ,  A61K31/7004

    摘要： [PROBLEMS] To provide a composition for inhibiting the onset of arteriosclerosis by using a rare sugar D-psicose and an inhibition method. [MEANS FOR SOLVING PROBLEMS] A composition for inhibiting the onset of arteriosclerosis characterized by comprising, as the active ingredient, D-psicose having antiatherogenic effects. The antiatherogenic effects as described above include an effect of inhibiting or lessening the expression of a chemokine or a cytokine relating to arteriosclerosis in vivo and an effect of promoting the expression of a receptor participating in the amelioration of arteriosclerosis without affecting the expression of an arteriosclerosis inducer. This composition is used in the form of a product selected from the group consisting of sweeteners, seasonings, food additives, food materials, foods, drinks, health foods and drinks, drugs, quasi drugs and feeds containing D-psicose and/or its derivative and/or a mixture thereof. A method of inhibiting the onset of arteriosclerosis by using the above composition.

    摘要翻译： 本发明提供一种通过使用稀有糖D-psicose抑制动脉硬化发作的组合物和抑制动脉硬化发作的方法。 [解决手段]用于抑制动脉硬化发作的组合物的特征在于，含有作为抗动脉粥样硬化作用的活性成分的D-灵芝蛋白。 如上所述的抗动脉粥样硬化作用包括抑制或降低与体内动脉硬化相关的趋化因子或细胞因子的表达的作用，以及促进动脉硬化改善的受体的表达的作用，而不影响动脉硬化诱导剂的表达 。 该组合物以选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料，保健食品和饮料，药物，准药物和与D-psicose和/或其混合的饲料组合的产品的形式使用 衍生物和/或其混合物作为活性成分。 抑制动脉硬化发生的方法是使用上述组合物的方法。

    COMPLEX CRYSTALLINE SUGAR COMPRISING D-PSICOSE AND D-ALLOSE AND PROCESS FOR PRODUCTION OF THE SAME
    10.
    发明公开
    COMPLEX CRYSTALLINE SUGAR COMPRISING D-PSICOSE AND D-ALLOSE AND PROCESS FOR PRODUCTION OF THE SAME 有权
    COMPLEX，D-阿洛酮糖和D-阿洛糖含有结晶糖和方法及其生产

    公开(公告)号：EP1860195A4

    公开(公告)日：2011-10-19

    申请号：EP06715211

    申请日：2006-03-03

    申请人： UNIV KAGAWA NAT UNIV CORP ,  MATSUTANI KAGAKU KOGYO KK

    发明人： IZUMORI KEN ,  TOKUDA MASAAKI ,  TAKADA GORO ,  MORIMOTO KENJI

    IPC分类号： C12P19/02 ,  C12P19/24 ,  C12R1/38

    CPC分类号： C12P19/02 ,  C12P19/24

    摘要： Disclosed is a process for producing a crystalline sugar comprising D-psicose and D-allose. Also disclosed is a process for producing the sugar. A complex crystalline sugar comprising D-psicose and D-allose. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.