公开(公告)号：EP3043863A4

公开(公告)日：2017-05-17

申请号：EP14844431

申请日：2014-09-11

申请人： UNIV LELAND STANFORD JUNIOR

发明人： FAHRIG REBECCA ,  LOO BILLY WISEMAN ,  MAXIM PETER G ,  TANTAWI SAMI

IPC分类号： A61N5/10 ,  A61N7/02 ,  G21K5/04 ,  H05H1/00 ,  H05H9/04 ,  H05H15/00

CPC分类号： A61N5/1084 ,  A61N5/1039 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/1078 ,  A61N5/1081 ,  A61N7/02 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1076 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098 ,  H05H9/048 ,  H05H2007/048

摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.

摘要翻译： 本文提供了用于促进快速辐射治疗的方法和系统，并且具体涉及辐射产生和输送，电子源设计，束控制和成形/强度调制。 本文描述的方法和系统当与紧凑的高梯度，超高能量电子（VHEE）加速器和递送系统（以及相关处理）一起使用时特别有利，其能够使用全电磁波 或提供射频偏转转向; 或者当与通常用于光子放射疗法的能量范围的高电流电子加速器系统一起使用以产生更快速的强度调制光子放射治疗的递送时，可以在两种情况下递送全剂量或部分高剂量辐射 治疗足以快速冻结生理运动，但与常规光子疗法相比，具有相同或更好的剂量一致性或雕刻程度。

公开(公告)号：EP3043864A4

公开(公告)日：2017-07-26

申请号：EP14876485

申请日：2014-09-11

申请人： UNIV LELAND STANFORD JUNIOR

发明人： BHARADWAJ VINOD ,  DOLGASHEV VALERY A ,  FAHRIG REBECCA ,  LOO BILLY WISEMAN ,  MAXIM PETER G ,  TANTAWI SAMI ,  LIMBORG CECILE ,  NICOLAS LUDOVIC

IPC分类号： A61N5/10 ,  G21K5/04 ,  H05H1/00 ,  H05H7/04 ,  H05H9/04 ,  H05H15/00

CPC分类号： A61N5/1084 ,  A61N5/1039 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/1078 ,  A61N5/1081 ,  A61N7/02 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1076 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098 ,  H05H9/048 ,  H05H2007/048

摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.

摘要翻译： 本文提供了用于促进快速辐射治疗的方法和系统，并且具体涉及辐射产生和输送，电子源设计，束控制和成形/强度调制。 本文描述的方法和系统当与紧凑的高梯度，超高能量电子（VHEE）加速器和递送系统（以及相关处理）一起使用时特别有利，其能够使用全电磁波 或提供射频偏转转向; 或者当与通常用于光子放射疗法的能量范围的高电流电子加速器系统一起使用以产生更快速的强度调制光子放射治疗的递送时，可以在两种情况下递送全剂量或部分高剂量辐射 治疗足以快速冻结生理运动，但与常规光子疗法相比，具有相同或更好的剂量一致性或雕刻程度。

公开(公告)号：EP2823501A4

公开(公告)日：2015-10-21

申请号：EP13757604

申请日：2013-02-12

申请人： UNIV LELAND STANFORD JUNIOR

发明人： LOO BILLY WISEMAN ,  MAXIM PETER G ,  DOLGASHEV VALERY A

IPC分类号： H01J3/32 ,  A61B6/00 ,  A61N5/10 ,  G21K1/08

CPC分类号： A61N5/1064 ,  A61N5/1043 ,  A61N5/1065 ,  A61N5/1081 ,  A61N2005/1051 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1076 ,  A61N2005/1088 ,  A61N2005/1089 ,  G21K5/04

摘要： A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose.

摘要翻译： 提供了一种紧凑的高梯度，高能量电子（VHEE）加速器和输送系统（以及相关过程），可以使用全电磁或射频偏转转向，以高速度对多个波束方向的患者进行治疗，可以提供整个 高剂量放射治疗的剂量或分数足够快以冻结生理运动，但比常规光子疗法具有更好的剂量一致性或雕刻程度。 除了极快的辐射传递的独特物理优点之外，对于相同的物理辐射剂量，在更大的肿瘤或其它目标控制功效方面也可能具有放射生物学优点。