专利检索 ap:("UNIV MARYLAND") AND inv:"VAN DYKE ADAM" 第 1 页

1.

发明公开
USE OF NEGATIVE MODULATORS OF GABA RECEPTORS CONTAINING ALPHA5 SUBUNITS AS FAST ACTING ANTIDEPRESSANTS 审中-公开

公开(公告)号：EP3125902A4

公开(公告)日：2018-01-24

申请号：EP15774070

申请日：2015-03-31

申请人： UNIV MARYLAND

发明人： THOMPSON SCOTT , KVARTA MARK D , VAN DYKE ADAM

IPC分类号： A61K31/55 , A61K31/515 , A61K31/56 , A61P25/00 , A61P25/22 , A61P25/24

CPC分类号： A61K31/5517 , A61K31/4375 , A61K31/455 , A61K31/53 , A61K45/06

摘要： Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a partial inverse agonist of a GABAA receptor comprising an alpha5 subunit.