公开(公告)号：EP3210024A4

公开(公告)日：2018-04-04

申请号：EP15852876

申请日：2015-10-07

申请人： UNIV MARYLAND ,  UNIV MARYLAND

发明人： MARTIN STUART ,  JEWELL CHRISTOPHER M ,  ANDORKO JAMES I ,  SOOKLAL ELISABETH LILY ,  WHIPPLE BETTES REBECCA ,  CHAKRABARTI KRISTI

IPC分类号： C12N5/09 ,  A61B5/00 ,  G01N21/95 ,  G01N33/50 ,  G01N33/574 ,  G02B21/00

CPC分类号： G01N33/5091 ,  G01N33/54353 ,  G01N2800/7028

摘要： The present invention provides a device for assaying living cells comprising a substrate, wherein the substrate comprises one or more tethering molecules which adhere to the substrate and are capable of interacting with cell membranes of the cells, wherein the cells maintain a free-floating, non-adherent character when bound to the one or more tethering molecules.

公开(公告)号：EP3166648A4

公开(公告)日：2018-05-30

申请号：EP15819202

申请日：2015-07-08

申请人： UNIV MARYLAND ,  UNIV MARYLAND

发明人： MASRI RADI ,  DEPIREUX DIDIER

IPC分类号： A61K48/00 ,  A61C5/50 ,  A61C19/06 ,  A61C19/08 ,  A61K9/00 ,  A61K9/50 ,  A61K31/155 ,  A61K41/00 ,  A61K47/69 ,  A61M19/00 ,  A61M37/00 ,  A61N2/00 ,  A61N2/02 ,  A61N2/06

CPC分类号： A61M37/00 ,  A61C5/50 ,  A61C19/06 ,  A61C19/063 ,  A61C19/08 ,  A61K9/0063 ,  A61K9/5094 ,  A61K31/155 ,  A61K41/00 ,  A61K47/48884 ,  A61K47/6923 ,  A61K47/6929 ,  A61M19/00 ,  A61M2037/0007 ,  A61M2210/0637 ,  A61N2/008 ,  A61N2/02 ,  A61N2/06

摘要： The present invention provides a method of treating a condition affecting a tooth or periodontium in a subject, comprising administering to the subject's tooth or periodontium a composition comprising biocompatible magnetic, magnetizable, or magnetically responsive agents; and applying an external magnetic field, wherein the magnetic, magnetizable, or magnetically responsive agents migrate to a desired location in response to the externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject.

公开(公告)号：EP1896832A4

公开(公告)日：2011-12-14

申请号：EP06773499

申请日：2006-06-19

申请人： UNIV MARYLAND BIOTECH INST ,  UNIV MARYLAND

发明人： GEDDES CHRIS D ,  AMIN SANJIV

IPC分类号： G01N21/64 ,  C12Q1/68 ,  G01N21/76 ,  G01N33/00 ,  G01N33/72

CPC分类号： G01N21/6428 ,  G01N21/648 ,  G01N33/728 ,  G01N2021/6432 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T436/145555 ,  Y10T436/146666

公开(公告)号：EP2035034A4

公开(公告)日：2009-11-18

申请号：EP07812088

申请日：2007-06-09

申请人： UNIV MARYLAND ,  UNIV MARYLAND BIOTECH INST

发明人： STROME SCOTT ,  WANG LAI-XI

IPC分类号： A61K39/00

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/53 ,  C07K2317/72 ,  C07K2317/732

公开(公告)号：EP1309719A4

公开(公告)日：2007-03-07

申请号：EP01961662

申请日：2001-08-14

申请人： UNIV MARYLAND AT BALTIMORE COU ,  UNIV MARYLAND BIOTECH INST

发明人： RAO GOVIND

IPC分类号： C12M1/34 ,  C12M1/36 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/82 ,  G01N33/52 ,  G01N35/00

CPC分类号： G01N21/253 ,  C12M23/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/34 ,  G01N21/643 ,  G01N21/6452 ,  G01N21/76 ,  G01N21/82 ,  G01N33/52 ,  G01N2021/6482

摘要： The invention bioprocessing system and technique relies on non-invasive optical chemical sensing technology wherein an optical excitation source excites an optical chemical sensor. The optical chemical sensor then emits luminescence or absorbs light which is measured by a detector. The luminescence emitted from the chemical sensor or the amount of light absorbed by the chemical sensor is related to the concentration of an analyte, such as oxygen. If the luminescence emitted changes, or if the amount of light absorbed changes, then the concentration of the analyte has changed. Using such a system to measure and adjust multiple parameters at one time allows one to efficiently and cost-effectively determine optimal conditions for a given cell type and/or cell environment. By combining cell cultivation with optical chemical sensing technology, cultivation can be successfully and rapidly performed, controlled and monitored in small volumes in an automated, parallel fashion at less expense than current bioprocess techniques. Figure (1) is a schematic diagram of a high throughput microbioprocessing system in accordance with one embodiment of the present invention.

公开(公告)号：EP2968370A4

公开(公告)日：2016-09-21

申请号：EP14768511

申请日：2014-03-14

申请人： UNIV MARYLAND ,  UNIV MARYLAND ,  UNIV JEFFERSON

发明人： NJAR VINCENT C O ,  GEDIYA LALJI K ,  PURUSHOTTAMACHAR PURANIK ,  GODBOLE ABHIJIT ,  KWEGYIR-AFFUL ANDREW ,  VASAITIS TADAS

IPC分类号： A61K31/58 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/58 ,  A61K45/06 ,  A61N5/10 ,  C07J43/003 ,  A61K2300/00

摘要： The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.

公开(公告)号：EP3212194A4

公开(公告)日：2018-06-20

申请号：EP15855662

申请日：2015-10-27

申请人： UNIV MARYLAND

发明人： CAO KAN

IPC分类号： A61K31/54 ,  A61K31/436 ,  A61K31/5415 ,  A61P17/00

CPC分类号： A61K31/5415 ,  A61K8/06 ,  A61K8/49 ,  A61K8/4926 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/10 ,  A61K9/107 ,  A61K31/436 ,  A61K2800/92 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  A61K2300/00

摘要： A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a composition containing an effective amount of at least methylene blue.

公开(公告)号：EP3207046A4

公开(公告)日：2018-06-13

申请号：EP15850784

申请日：2015-10-19

申请人： UNIV MARYLAND ,  MASSACHUSETTS GEN HOSPITAL

发明人： ISAACS LYLE DAVID ,  EIKERMANN MATTHIAS ,  CUSIN CRISTINA ,  COTTEN JOSEPH

IPC分类号： C07D487/22 ,  A61K31/4188 ,  A61K31/551 ,  A61K31/787 ,  A61K47/60 ,  A61P25/30 ,  A61P25/36 ,  C07D487/14

CPC分类号： A61K31/551 ,  A61K31/4188 ,  A61K31/787 ,  A61K47/48215 ,  A61K47/60

摘要： Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.

公开(公告)号：EP3132049A4

公开(公告)日：2018-03-21

申请号：EP15779256

申请日：2015-04-17

申请人： UNIV MARYLAND ,  CHILDRENS NAT MEDICAL CENTER

发明人： AYYUB OMAR BILAL ,  HELIGMAN BRIAN THEODORE ,  KOFINAS PETER ,  SUMMAR MARSHALL LYNN ,  CABRERA LUQUE JUAN MANUEL ,  CUNNINGHAM GARY

IPC分类号： G01N33/52 ,  C12Q1/32 ,  G01N33/68

CPC分类号： C12Q1/005 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0887 ,  C12Q1/32 ,  G01N33/523 ,  G01N33/6812 ,  G01N33/6893 ,  G01N2333/902 ,  G01N2333/904 ,  G01N2333/90622 ,  G01N2800/04 ,  G01N2800/52

摘要： The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of metabolic enzymes or functional fragments thereof, but wherein the reaction surface does not comprise an electrode or electrically conductive support. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the reaction surface.

公开(公告)号：EP3200801A4

公开(公告)日：2018-03-07

申请号：EP15845704

申请日：2015-10-02

申请人： UNIV MARYLAND

发明人： NJAR VINCENT C O ,  PURUSHOTTAMACHAR PURANIK ,  KWEGYIR-AFFUL ANDREW K

IPC分类号： A61K31/56 ,  A61K31/58 ,  A61P35/00

CPC分类号： C07J43/003 ,  A61K31/58 ,  A61K31/7068 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods may comprise administering ARDA compounds to the subject.