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公开(公告)号：EP2748176A4
公开(公告)日：2015-09-16
申请号：EP12824951
申请日：2012-08-23
发明人： DAMHA MASAD J , HASSLER MATTHEW , CHAN TAK-HANG , REDDY N MALLIKARJUNA , DONGA ROBERT ALEXANDER
CPC分类号： C07F9/54 , C07D233/60 , C07F9/5407 , C07F9/5442 , C07F9/5456 , C07F9/65515 , C07F9/65586 , C07H19/02 , C07H21/00 , C07H21/02 , C40B50/16 , C40B80/00
摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
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公开(公告)号：EP1861413A4
公开(公告)日：2010-04-28
申请号：EP06705308
申请日：2006-03-15
发明人： CHAN TAK-HANG , DAMHA MASAD J , MIAO WEISHI , DONGA ROBERT ALEXANDER , HE XUN
CPC分类号： C07H21/00 , C07H3/06 , C07K1/023 , C07K1/04 , Y02P20/542
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3.发明公开OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF 有权寡核苷酸双链体与DNA和RNA相似相似的核苷酸及其用途
公开(公告)号：EP2294195A4
公开(公告)日：2012-12-19
申请号：EP09757018
申请日：2009-06-05
申请人： UNIV MCGILL
发明人： DAMHA MASAD J , WATTS JONATHAN K , DELEAVEY GLEN
CPC分类号： C12N15/113 , C07H21/00 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/322 , C12N2310/323 , C12N2320/30 , C12N2320/51 , C12N2320/53
摘要： Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2′-sub-stituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2′-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
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公开(公告)号：EP1931694A4
公开(公告)日：2009-12-16
申请号：EP06790795
申请日：2006-10-03
申请人： UNIV MCGILL
发明人： DAMHA MASAD J , PENG CHANG GENG
IPC分类号： C07H21/04 , A61K31/7088 , A61K31/712 , A61K48/00 , A61P7/02 , A61P31/18 , A61P35/00 , C07H21/02 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/115 , C12N2310/151 , C12N2310/16 , C12N2310/322 , C12N2310/323
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公开(公告)号：EP2609107A4
公开(公告)日：2014-03-19
申请号：EP11819230
申请日：2011-08-23
申请人： UNIV MCGILL
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